Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385758839> ?p ?o ?g. }
- W4385758839 abstract "Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which often affects the lung, and coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), stand out as major drivers of epidemics of global concern. Despite their unrelated etiology and distinct pathology, these infections affect the same vital organ and share immunopathogenesis traits and an imperative demand to model the diseases at their various progression stages and localizations. Due to the clinical spectrum and heterogeneity of both diseases experimental infections were pursued in a variety of animal models. We summarize mammalian models employed in TB and COVID-19 experimental investigations, highlighting the diversity of rodent models and species peculiarities for each infection. We discuss the utility of non-human primates for translational research and emphasize on the benefits of non-conventional experimental models such as livestock. We epitomize advances facilitated by animal models with regard to understanding disease pathophysiology and immune responses. Finally, we highlight research areas necessitating optimized models and advocate that research of pulmonary infectious diseases could benefit from cross-fertilization between studies of apparently unrelated diseases, such as TB and COVID-19." @default.
- W4385758839 created "2023-08-12" @default.
- W4385758839 creator A5001905405 @default.
- W4385758839 creator A5022339560 @default.
- W4385758839 creator A5036973907 @default.
- W4385758839 creator A5037230655 @default.
- W4385758839 creator A5042783634 @default.
- W4385758839 date "2023-08-11" @default.
- W4385758839 modified "2023-10-15" @default.
- W4385758839 title "Animal models for COVID-19 and tuberculosis" @default.
- W4385758839 cites W1498486243 @default.
- W4385758839 cites W1510711119 @default.
- W4385758839 cites W1521656984 @default.
- W4385758839 cites W1533182067 @default.
- W4385758839 cites W1550604254 @default.
- W4385758839 cites W1832284734 @default.
- W4385758839 cites W1915399536 @default.
- W4385758839 cites W1917802511 @default.
- W4385758839 cites W1918789384 @default.
- W4385758839 cites W1920434477 @default.
- W4385758839 cites W1964693504 @default.
- W4385758839 cites W1965341242 @default.
- W4385758839 cites W1969623044 @default.
- W4385758839 cites W1971522764 @default.
- W4385758839 cites W1973146464 @default.
- W4385758839 cites W1973225312 @default.
- W4385758839 cites W1973241546 @default.
- W4385758839 cites W1980748590 @default.
- W4385758839 cites W1982952028 @default.
- W4385758839 cites W1988906407 @default.
- W4385758839 cites W1990067365 @default.
- W4385758839 cites W1992799735 @default.
- W4385758839 cites W2007186942 @default.
- W4385758839 cites W2009737104 @default.
- W4385758839 cites W2014816257 @default.
- W4385758839 cites W2017850593 @default.
- W4385758839 cites W2022251703 @default.
- W4385758839 cites W2023216836 @default.
- W4385758839 cites W2025755851 @default.
- W4385758839 cites W2025969665 @default.
- W4385758839 cites W2026233736 @default.
- W4385758839 cites W2026954989 @default.
- W4385758839 cites W2027490141 @default.
- W4385758839 cites W2029256332 @default.
- W4385758839 cites W2035275046 @default.
- W4385758839 cites W2035732237 @default.
- W4385758839 cites W2036740408 @default.
- W4385758839 cites W2038535814 @default.
- W4385758839 cites W2053260379 @default.
- W4385758839 cites W2053666360 @default.
- W4385758839 cites W2055224823 @default.
- W4385758839 cites W2058083167 @default.
- W4385758839 cites W2059359466 @default.
- W4385758839 cites W2063593097 @default.
- W4385758839 cites W2064698809 @default.
- W4385758839 cites W2065100101 @default.
- W4385758839 cites W2066033587 @default.
- W4385758839 cites W2066388620 @default.
- W4385758839 cites W2066836422 @default.
- W4385758839 cites W2075072767 @default.
- W4385758839 cites W2075482744 @default.
- W4385758839 cites W2075819557 @default.
- W4385758839 cites W2078676553 @default.
- W4385758839 cites W2080595107 @default.
- W4385758839 cites W2081119657 @default.
- W4385758839 cites W2085150115 @default.
- W4385758839 cites W2087949108 @default.
- W4385758839 cites W2089226849 @default.
- W4385758839 cites W2089532656 @default.
- W4385758839 cites W2090051979 @default.
- W4385758839 cites W2090234824 @default.
- W4385758839 cites W2090304438 @default.
- W4385758839 cites W2092448486 @default.
- W4385758839 cites W2097023349 @default.
- W4385758839 cites W2097333857 @default.
- W4385758839 cites W2098424125 @default.
- W4385758839 cites W2099195467 @default.
- W4385758839 cites W2100531445 @default.
- W4385758839 cites W2100872199 @default.
- W4385758839 cites W2101594752 @default.
- W4385758839 cites W2105228567 @default.
- W4385758839 cites W2106684755 @default.
- W4385758839 cites W2109421133 @default.
- W4385758839 cites W2109531704 @default.
- W4385758839 cites W2109543073 @default.
- W4385758839 cites W2109684750 @default.
- W4385758839 cites W2113265821 @default.
- W4385758839 cites W2117328868 @default.
- W4385758839 cites W2118543713 @default.
- W4385758839 cites W2118752598 @default.
- W4385758839 cites W2121476879 @default.
- W4385758839 cites W2124804703 @default.
- W4385758839 cites W2125089546 @default.
- W4385758839 cites W2125635434 @default.
- W4385758839 cites W2126488454 @default.
- W4385758839 cites W2129996072 @default.
- W4385758839 cites W2130046741 @default.
- W4385758839 cites W2130764794 @default.
- W4385758839 cites W2131393876 @default.
- W4385758839 cites W2131926746 @default.