FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385759253> ?p ?o ?g. }

• W4385759253 endingPage "1143" @default.
• W4385759253 startingPage "1134" @default.
• W4385759253 abstract "Our group has previously demonstrated elevated serum-soluble ST2 in patients with active systemic lupus erythematosus, suggesting a role of IL-33 in the underlying pathogenesis. However, inconsistent results have been reported on the effect of exogenous IL-33 on murine lupus activity, which may be mediated by concerted actions of various immune cells in vivo. This study aimed to examine the function of IL-33 on macrophage polarization and regulatory T cells (Treg) and their interactive effects in the lupus setting by in vitro coculture experiments of macrophages and T cells that were performed in the presence or absence of IL-33-containing medium. Compared to IL-4-polarized bone marrow-derived macrophages (BMDM) from MRL/MpJ mice, adding IL-33 enhanced mRNA expression of markers of alternatively activated macrophages, including CD206 and Arg1. IL-33 and IL-4 copolarized BMDM produced higher TGF-β but not IL-6 upon inflammatory challenge. These BMDM induced an increase in the Foxp3+CD25+ Treg population in cocultured allogeneic T cells from MRL/MpJ and predisease MRL/lpr mice. These copolarized BMDM also showed an enhanced suppressive effect on T cell proliferation with reduced IFN-γ and IL-17 release but increased TGF-β production. In the presence of TGF-β and IL-2, IL-33 also directly promoted inducible Treg that expressed a high level of CD25 and more sustained Foxp3. Unpolarized BMDM cocultured with these Treg displayed higher phagocytosis. In conclusion, TGF-β was identified as a key cytokine produced by IL-4 and IL-33 copolarized alternatively activated macrophages and the induced Treg, which may contribute to a positive feedback loop potentiating the immunoregulatory functions of IL-33." @default.
• W4385759253 created "2023-08-12" @default.
• W4385759253 creator A5013402490 @default.
• W4385759253 creator A5021411903 @default.
• W4385759253 creator A5023769086 @default.
• W4385759253 creator A5030859363 @default.
• W4385759253 creator A5072149062 @default.
• W4385759253 date "2023-08-11" @default.
• W4385759253 modified "2023-10-03" @default.
• W4385759253 title "IL-33 Orchestrated the Interaction and Immunoregulatory Functions of Alternatively Activated Macrophages and Regulatory T Cells In Vitro" @default.
• W4385759253 cites W1189796049 @default.
• W4385759253 cites W1516197123 @default.
• W4385759253 cites W1518095394 @default.
• W4385759253 cites W1555151769 @default.
• W4385759253 cites W1810971862 @default.
• W4385759253 cites W1855313929 @default.
• W4385759253 cites W1881636432 @default.
• W4385759253 cites W1922740069 @default.
• W4385759253 cites W1970555542 @default.
• W4385759253 cites W1979980398 @default.
• W4385759253 cites W1983312277 @default.
• W4385759253 cites W1983484216 @default.
• W4385759253 cites W1986725618 @default.
• W4385759253 cites W1993751578 @default.
• W4385759253 cites W1998752508 @default.
• W4385759253 cites W2004708987 @default.
• W4385759253 cites W2011451239 @default.
• W4385759253 cites W2011923903 @default.
• W4385759253 cites W2018352403 @default.
• W4385759253 cites W2020887684 @default.
• W4385759253 cites W2023237958 @default.
• W4385759253 cites W2038689279 @default.
• W4385759253 cites W2043044540 @default.
• W4385759253 cites W2058065781 @default.
• W4385759253 cites W2063746539 @default.
• W4385759253 cites W2065210647 @default.
• W4385759253 cites W2068898313 @default.
• W4385759253 cites W2073666097 @default.
• W4385759253 cites W2077501713 @default.
• W4385759253 cites W2079374732 @default.
• W4385759253 cites W2084575069 @default.
• W4385759253 cites W2096630412 @default.
• W4385759253 cites W2102541996 @default.
• W4385759253 cites W2120316424 @default.
• W4385759253 cites W2132247162 @default.
• W4385759253 cites W2134383687 @default.
• W4385759253 cites W2157710399 @default.
• W4385759253 cites W2158300165 @default.
• W4385759253 cites W2159560463 @default.
• W4385759253 cites W2163863824 @default.
• W4385759253 cites W2163984243 @default.
• W4385759253 cites W2165909284 @default.
• W4385759253 cites W2342000077 @default.
• W4385759253 cites W2416118992 @default.
• W4385759253 cites W2509961279 @default.
• W4385759253 cites W2604332021 @default.
• W4385759253 cites W2618671021 @default.
• W4385759253 cites W3043703035 @default.
• W4385759253 cites W3090162040 @default.
• W4385759253 cites W4323539007 @default.
• W4385759253 doi "https://doi.org/10.4049/jimmunol.2300191" @default.
• W4385759253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37566486" @default.
• W4385759253 hasPublicationYear "2023" @default.
• W4385759253 type Work @default.
• W4385759253 citedByCount "0" @default.
• W4385759253 crossrefType "journal-article" @default.
• W4385759253 hasAuthorship W4385759253A5013402490 @default.
• W4385759253 hasAuthorship W4385759253A5021411903 @default.
• W4385759253 hasAuthorship W4385759253A5023769086 @default.
• W4385759253 hasAuthorship W4385759253A5030859363 @default.
• W4385759253 hasAuthorship W4385759253A5072149062 @default.
• W4385759253 hasConcept C187316574 @default.
• W4385759253 hasConcept C202751555 @default.
• W4385759253 hasConcept C203014093 @default.
• W4385759253 hasConcept C2776090121 @default.
• W4385759253 hasConcept C2778690821 @default.
• W4385759253 hasConcept C2779244956 @default.
• W4385759253 hasConcept C2779727006 @default.
• W4385759253 hasConcept C2908647359 @default.
• W4385759253 hasConcept C55493867 @default.
• W4385759253 hasConcept C71924100 @default.
• W4385759253 hasConcept C79484868 @default.
• W4385759253 hasConcept C86803240 @default.
• W4385759253 hasConcept C8891405 @default.
• W4385759253 hasConcept C95444343 @default.
• W4385759253 hasConcept C99454951 @default.
• W4385759253 hasConceptScore W4385759253C187316574 @default.
• W4385759253 hasConceptScore W4385759253C202751555 @default.
• W4385759253 hasConceptScore W4385759253C203014093 @default.
• W4385759253 hasConceptScore W4385759253C2776090121 @default.
• W4385759253 hasConceptScore W4385759253C2778690821 @default.
• W4385759253 hasConceptScore W4385759253C2779244956 @default.
• W4385759253 hasConceptScore W4385759253C2779727006 @default.
• W4385759253 hasConceptScore W4385759253C2908647359 @default.
• W4385759253 hasConceptScore W4385759253C55493867 @default.
• W4385759253 hasConceptScore W4385759253C71924100 @default.
• W4385759253 hasConceptScore W4385759253C79484868 @default.
• W4385759253 hasConceptScore W4385759253C86803240 @default.

• next