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- W4385759946 endingPage "2044" @default.
- W4385759946 startingPage "2044" @default.
- W4385759946 abstract "Cyclins and cyclin-dependent kinases (CDKs) play versatile roles in promoting the hallmarks of cancer. Therefore, cyclins and CDKs have been widely studied and targeted in cancer treatment, with four CDK4/6 inhibitors being approved by the FDA and many other inhibitors being examined in clinical trials. The specific purpose of this review is to delineate the role and therapeutic potential of Cyclin K in cancers. Studies have shown that Cyclin K regulates many essential biological processes, including the DNA damage response, mitosis, and pre-replicative complex assembly, and is critical in both cancer cell growth and therapeutic resistance. Importantly, the druggability of Cyclin K has been demonstrated in an increasing number of studies that identify novel opportunities for its use in cancer treatment. This review first introduces the basic features and translational value of human cyclins and CDKs. Next, the discovery, phosphorylation targets, and related functional significance of Cyclin K-CDK12/13 complexes in cancer are detailed. This review then provides a summary of current Cyclin K-associated cancer studies, with an emphasis on the available Cyclin K-targeting drugs. Finally, the current knowledge gaps regarding the potential of Cyclin K in cancers are discussed, along with interesting directions for future investigation." @default.
- W4385759946 created "2023-08-12" @default.
- W4385759946 creator A5027840612 @default.
- W4385759946 creator A5056842955 @default.
- W4385759946 date "2023-08-11" @default.
- W4385759946 modified "2023-09-25" @default.
- W4385759946 title "Coming of Age: Targeting Cyclin K in Cancers" @default.
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- W4385759946 doi "https://doi.org/10.3390/cells12162044" @default.