FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385760156> ?p ?o ?g. }

• W4385760156 endingPage "4064" @default.
• W4385760156 startingPage "4064" @default.
• W4385760156 abstract "(1) Background: Autoantibodies to tumor-associated antigens (TAAs) have emerged as promising cancer biomarkers. Luminex technology offers a powerful approach for the simultaneous detection of multiple anti-TAA autoantibodies. (2) Methods: We aimed to utilize Luminex technology to evaluate and optimize a panel of anti-TAAs autoantibodies for detecting prostate cancer (PCa), which included autoantibodies to fourteen TAAs. A total of 163 serum samples (91 PCa, 72 normal controls) were screened to determine the levels of the autoantibodies using the Luminex assay. (3) Results: Twelve autoantibodies exhibited significantly high frequencies ranging from 19.8% to 51.6% in the PCa group. Receiver operating characteristic (ROC) curve analysis revealed area under the curve (AUC) values ranging from 0.609 to 0.868 for the twelve autoantibodies individually. We further confirmed the performance of the HSP60 autoantibody by using an enzyme-linked immunosorbent assay (ELISA) in a larger sample comprising 200 PCa sera, 20 benign prostatic hyperplasia (BPH) sera, and 137 normal control sera. The results obtained from the Luminex assay were consistent with the ELISA findings. We developed a panel consisting of three autoantibodies (p16, IMP2, and HSP60) which achieved an impressive AUC of 0.910 with a sensitivity of 71.4% and a specificity of 95.8%. The panel was also evaluated in PCa patients from different races/ethnicities with the best performance observed in distinguishing the Hispanic American patients with PCa from normal controls. (4) Conclusions: We developed an anti-TAA autoantibody panel for the detection of PCa that exhibits promising performance. This panel holds significant potential as a high-throughput tool to facilitate PCa detection." @default.
• W4385760156 created "2023-08-12" @default.
• W4385760156 creator A5004300870 @default.
• W4385760156 creator A5015631803 @default.
• W4385760156 creator A5023105695 @default.
• W4385760156 creator A5039762207 @default.
• W4385760156 creator A5052221681 @default.
• W4385760156 creator A5058010200 @default.
• W4385760156 creator A5075999310 @default.
• W4385760156 date "2023-08-11" @default.
• W4385760156 modified "2023-10-14" @default.
• W4385760156 title "A Luminex Approach to Develop an Anti-Tumor-Associated Antigen Autoantibody Panel for the Detection of Prostate Cancer in Racially/Ethnically Diverse Populations" @default.
• W4385760156 cites W1944351535 @default.
• W4385760156 cites W1966528088 @default.
• W4385760156 cites W1996762218 @default.
• W4385760156 cites W2014523497 @default.
• W4385760156 cites W2023138618 @default.
• W4385760156 cites W2026097784 @default.
• W4385760156 cites W2033106731 @default.
• W4385760156 cites W2035881032 @default.
• W4385760156 cites W2046246310 @default.
• W4385760156 cites W2052977372 @default.
• W4385760156 cites W2062977833 @default.
• W4385760156 cites W2097599145 @default.
• W4385760156 cites W2105172077 @default.
• W4385760156 cites W2133794613 @default.
• W4385760156 cites W2134546050 @default.
• W4385760156 cites W2135504462 @default.
• W4385760156 cites W2145658629 @default.
• W4385760156 cites W2148915125 @default.
• W4385760156 cites W2150597665 @default.
• W4385760156 cites W2164019499 @default.
• W4385760156 cites W2196767141 @default.
• W4385760156 cites W2293039002 @default.
• W4385760156 cites W2490949080 @default.
• W4385760156 cites W2511013437 @default.
• W4385760156 cites W2529979227 @default.
• W4385760156 cites W2594170573 @default.
• W4385760156 cites W2937997180 @default.
• W4385760156 cites W2982659288 @default.
• W4385760156 cites W3000074159 @default.
• W4385760156 cites W3008204971 @default.
• W4385760156 cites W3091966002 @default.
• W4385760156 cites W3128646645 @default.
• W4385760156 cites W3129886164 @default.
• W4385760156 cites W3169381744 @default.
• W4385760156 cites W3174956789 @default.
• W4385760156 cites W3199050716 @default.
• W4385760156 cites W3207326847 @default.
• W4385760156 cites W3207771345 @default.
• W4385760156 cites W4210440569 @default.
• W4385760156 cites W4226072750 @default.
• W4385760156 cites W4226367998 @default.
• W4385760156 cites W4243087891 @default.
• W4385760156 cites W4303876188 @default.
• W4385760156 cites W4306366834 @default.
• W4385760156 cites W4320492791 @default.
• W4385760156 cites W4327582643 @default.
• W4385760156 doi "https://doi.org/10.3390/cancers15164064" @default.
• W4385760156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37627091" @default.
• W4385760156 hasPublicationYear "2023" @default.
• W4385760156 type Work @default.
• W4385760156 citedByCount "0" @default.
• W4385760156 crossrefType "journal-article" @default.
• W4385760156 hasAuthorship W4385760156A5004300870 @default.
• W4385760156 hasAuthorship W4385760156A5015631803 @default.
• W4385760156 hasAuthorship W4385760156A5023105695 @default.
• W4385760156 hasAuthorship W4385760156A5039762207 @default.
• W4385760156 hasAuthorship W4385760156A5052221681 @default.
• W4385760156 hasAuthorship W4385760156A5058010200 @default.
• W4385760156 hasAuthorship W4385760156A5075999310 @default.
• W4385760156 hasBestOaLocation W43857601561 @default.
• W4385760156 hasConcept C121608353 @default.
• W4385760156 hasConcept C126322002 @default.
• W4385760156 hasConcept C147483822 @default.
• W4385760156 hasConcept C159654299 @default.
• W4385760156 hasConcept C163764329 @default.
• W4385760156 hasConcept C203014093 @default.
• W4385760156 hasConcept C2780192828 @default.
• W4385760156 hasConcept C2781406297 @default.
• W4385760156 hasConcept C58471807 @default.
• W4385760156 hasConcept C71924100 @default.
• W4385760156 hasConcept C76318530 @default.
• W4385760156 hasConceptScore W4385760156C121608353 @default.
• W4385760156 hasConceptScore W4385760156C126322002 @default.
• W4385760156 hasConceptScore W4385760156C147483822 @default.
• W4385760156 hasConceptScore W4385760156C159654299 @default.
• W4385760156 hasConceptScore W4385760156C163764329 @default.
• W4385760156 hasConceptScore W4385760156C203014093 @default.
• W4385760156 hasConceptScore W4385760156C2780192828 @default.
• W4385760156 hasConceptScore W4385760156C2781406297 @default.
• W4385760156 hasConceptScore W4385760156C58471807 @default.
• W4385760156 hasConceptScore W4385760156C71924100 @default.
• W4385760156 hasConceptScore W4385760156C76318530 @default.
• W4385760156 hasIssue "16" @default.
• W4385760156 hasLocation W43857601561 @default.
• W4385760156 hasLocation W43857601562 @default.
• W4385760156 hasOpenAccess W4385760156 @default.

• next