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- W4385760207 endingPage "118369" @default.
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- W4385760207 abstract "Regulating redox homeostasis is an advanced and efficient approach for cancer treatment. Well-designed catalytic drugs, which can catalytic generation of reactive oxygen species (ROS) in targeted cells, minimizing side effects, are urgently needed. Here, we developed a near infrared (NIR) carbon dot-based oxidative stress amplifier (named AptCND-Cu) for targeted cellular imaging and intracellular generation of ROS. AptCND-Cu was designed and prepared through a controllable double-covalent modification of NIR CNDs with a DNA aptamer and Cu complex. Detailed characterization techniques, including TEM, AFM, XPS and DLS, were used to confirm the successful coupling of both oligomer aptamer and metal complex. The resulting AptCND-Cu owns superior tumor targeting, stable NIR fluorescence (FL) emission, good photostability, and stable copper delivery. We demonstrate that this material can deplete glutathione (GSH) and can amplify Cu-induced Fenton-like reaction eventually causing cell death in vitro. AptCND-Cu exhibit also long tumor retention time in tumor-bearing mice and enhanced body clearance. This work not only propose an alternative strategy to the multifunctionalization of red-emissive CNDs, by simply integrating DNA and ion-based catalytic drugs, but also broadens their uses in cancer catalytic nanomedicine." @default.
- W4385760207 created "2023-08-12" @default.
- W4385760207 creator A5017462048 @default.
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- W4385760207 date "2023-10-01" @default.
- W4385760207 modified "2023-10-17" @default.
- W4385760207 title "Engineered DNA-copper double-modified NIR carbon nanodots as oxidative stress amplifier for targeted intracellular production of reactive oxygen species" @default.
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- W4385760207 doi "https://doi.org/10.1016/j.carbon.2023.118369" @default.
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