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- W4385761721 abstract "Despite the low incidence of soft tissue sarcomas (STSs), hundreds of thousands of new STS cases are diagnosed annually worldwide, and approximately half of them eventually progress to advanced stages. Currently, chemotherapy is the first-line treatment for advanced STSs. There are difficulties in selecting appropriate drugs for multiline chemotherapy, or for combination treatment of different STS histological subtypes. In this study, we first comprehensively reviewed the efficacy of various chemotherapeutic drugs in the treatment of STSs, and then described the current status of sensitive drugs for different STS subtypes. anthracyclines are the most important systemic treatment for advanced STSs. Ifosfamide, trabectedin, gemcitabine, taxanes, dacarbazine, and eribulin exhibit certain activities in STSs. Vinca alkaloid agents (vindesine, vinblastine, vinorelbine, vincristine) have important therapeutic effects in specific STS subtypes, such as rhabdomyosarcoma and Ewing sarcoma family tumors, whereas their activity in other subtypes is weak. Other chemotherapeutic drugs (methotrexate, cisplatin, etoposide, pemetrexed) have weak efficacy in STSs and are rarely used. It is necessary to select specific second- or above-line chemotherapeutic drugs depending on the histological subtype. This review aims to provide a reference for the selection of chemotherapeutic drugs for multi-line therapy for patients with advanced STSs who have an increasingly long survival." @default.
- W4385761721 created "2023-08-12" @default.
- W4385761721 creator A5000935535 @default.
- W4385761721 creator A5033735272 @default.
- W4385761721 date "2023-08-11" @default.
- W4385761721 modified "2023-09-25" @default.
- W4385761721 title "Chemotherapeutic drugs for soft tissue sarcomas: a review" @default.
- W4385761721 cites W1485857735 @default.
- W4385761721 cites W1589920570 @default.
- W4385761721 cites W1828438395 @default.
- W4385761721 cites W1873257876 @default.
- W4385761721 cites W1876135160 @default.
- W4385761721 cites W1882650898 @default.
- W4385761721 cites W1906474388 @default.
- W4385761721 cites W1911517772 @default.
- W4385761721 cites W1917401325 @default.
- W4385761721 cites W1929606469 @default.
- W4385761721 cites W1955072209 @default.
- W4385761721 cites W1964020503 @default.
- W4385761721 cites W1964505940 @default.
- W4385761721 cites W1965664244 @default.
- W4385761721 cites W1966107654 @default.
- W4385761721 cites W1966263910 @default.
- W4385761721 cites W1971335299 @default.
- W4385761721 cites W1974029074 @default.
- W4385761721 cites W1979105272 @default.
- W4385761721 cites W1979729949 @default.
- W4385761721 cites W1981319746 @default.
- W4385761721 cites W1990390825 @default.
- W4385761721 cites W1997366370 @default.
- W4385761721 cites W2002215444 @default.
- W4385761721 cites W2005686017 @default.
- W4385761721 cites W2008044750 @default.
- W4385761721 cites W2010948762 @default.
- W4385761721 cites W2012069610 @default.
- W4385761721 cites W2013000677 @default.
- W4385761721 cites W2017230914 @default.
- W4385761721 cites W2017697710 @default.
- W4385761721 cites W2018067088 @default.
- W4385761721 cites W2021087771 @default.
- W4385761721 cites W2026516892 @default.
- W4385761721 cites W2032255554 @default.
- W4385761721 cites W2034328882 @default.
- W4385761721 cites W2036064715 @default.
- W4385761721 cites W2046161634 @default.
- W4385761721 cites W2046633896 @default.
- W4385761721 cites W2047664336 @default.
- W4385761721 cites W2049025598 @default.
- W4385761721 cites W2049720267 @default.
- W4385761721 cites W2051496963 @default.
- W4385761721 cites W2063296444 @default.
- W4385761721 cites W2066491921 @default.
- W4385761721 cites W2069032250 @default.
- W4385761721 cites W2070871717 @default.
- W4385761721 cites W2071881462 @default.
- W4385761721 cites W2073672572 @default.
- W4385761721 cites W2080325319 @default.
- W4385761721 cites W2082065626 @default.
- W4385761721 cites W2085480583 @default.
- W4385761721 cites W2085739451 @default.
- W4385761721 cites W2091237838 @default.
- W4385761721 cites W2091453908 @default.
- W4385761721 cites W2092722132 @default.
- W4385761721 cites W2095607605 @default.
- W4385761721 cites W2095645261 @default.
- W4385761721 cites W2096279999 @default.
- W4385761721 cites W2096376289 @default.
- W4385761721 cites W2096442753 @default.
- W4385761721 cites W2096691972 @default.
- W4385761721 cites W2097409022 @default.
- W4385761721 cites W2098553441 @default.
- W4385761721 cites W2100986293 @default.
- W4385761721 cites W2102897174 @default.
- W4385761721 cites W2105567069 @default.
- W4385761721 cites W2106923265 @default.
- W4385761721 cites W2107078868 @default.
- W4385761721 cites W2112169652 @default.
- W4385761721 cites W2113795742 @default.
- W4385761721 cites W2116025938 @default.
- W4385761721 cites W2116194362 @default.
- W4385761721 cites W2117162062 @default.
- W4385761721 cites W2117431699 @default.
- W4385761721 cites W2117784457 @default.
- W4385761721 cites W2124148984 @default.
- W4385761721 cites W2131332934 @default.
- W4385761721 cites W2133154453 @default.
- W4385761721 cites W2135118095 @default.
- W4385761721 cites W2136344041 @default.
- W4385761721 cites W2139206468 @default.
- W4385761721 cites W2141084506 @default.
- W4385761721 cites W2150612025 @default.
- W4385761721 cites W2151384475 @default.
- W4385761721 cites W2151863911 @default.
- W4385761721 cites W2152070180 @default.
- W4385761721 cites W2153138245 @default.
- W4385761721 cites W2153365867 @default.
- W4385761721 cites W2154747925 @default.
- W4385761721 cites W2158920228 @default.
- W4385761721 cites W2160028990 @default.
- W4385761721 cites W2160752563 @default.