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- W4385764061 abstract "Mitochondria-associated membranes (MAMs), or mitochondria-endoplasmic reticulum (ER) contacts (MERCs), are dynamic structures representing biochemical and physical contacts between mitochondria and the ER. MAMs modulate several cellular events including lipid metabolism, Ca2+ signaling, proteostasis, stress response, and redox status. Disrupted MAMs have been implicated in Alzheimer disease (AD) physiopathology contributing to impaired lipid and glucose metabolism, aberrant Ca2+ homeostasis, ER stress, compromised autophagy, mitochondrial dysfunction, oxidative stress/damage, and apoptotic cell death. Since MAMs alterations seem to occur upstream of AD-associated events such as mitochondrial dysfunction and oxidative stress, therapies focusing on these signaling platforms can represent powerful tools to fight AD. In this chapter, we provide an overview of MAMs structure and functions, and we will discuss how altered MAMs contribute to ROS overproduction and redox deregulation in AD putting the focus on lipid oxidative damage. The therapeutic potential of strategies targeting MAMs will be also debated." @default.
- W4385764061 created "2023-08-12" @default.
- W4385764061 creator A5024602715 @default.
- W4385764061 creator A5040895843 @default.
- W4385764061 creator A5046560436 @default.
- W4385764061 creator A5053059798 @default.
- W4385764061 date "2023-01-01" @default.
- W4385764061 modified "2023-10-17" @default.
- W4385764061 title "Mitochondria-associated membranes (MAMs) as modulators of oxidative stress in Alzheimer disease" @default.
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