FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385767047> ?p ?o ?g. }

• W4385767047 abstract "ABSTRACT Antibodies are frontline defenders against influenza virus infection, providing protection through multiple complementary mechanisms. Although a subset of monoclonal antibodies (mAbs) have been shown to restrict replication at the level of virus assembly and release, it remains unclear how potent and pervasive this mechanism of protection is, due in part to the challenge of separating this effect from other aspects of antibody function. To address this question, we developed imaging-based assays to determine how effectively a broad range of mAbs against the IAV surface proteins can specifically restrict viral egress. We find that classically neutralizing antibodies against hemagglutinin are broadly multifunctional, inhibiting virus assembly and release at concentrations one- to twenty-fold higher than the concentrations at which they inhibit viral entry. These antibodies are also capable of altering the morphological features of shed virions, reducing the proportion of filamentous particles. We find that antibodies against neuraminidase and M2 also restrict viral egress, and that inhibition by anti-neuraminidase mAbs is only partly attributable to a loss in enzymatic activity. In all cases, antigen crosslinking – either on the surface of the infected cell, between the viral and cell membrane, or both - plays a critical role in inhibition, and we are able to distinguish between these modes experimentally and through a structure-based computational model. Together, these results provide a framework for dissecting antibody multifunctionality that could help guide the development of improved therapeutic antibodies or vaccines, and that can be extended to other viral families and antibody isotypes." @default.
• W4385767047 created "2023-08-12" @default.
• W4385767047 creator A5006689364 @default.
• W4385767047 creator A5041296481 @default.
• W4385767047 creator A5041350430 @default.
• W4385767047 creator A5045739357 @default.
• W4385767047 creator A5088268527 @default.
• W4385767047 date "2023-08-09" @default.
• W4385767047 modified "2023-09-28" @default.
• W4385767047 title "Antibody Inhibition of Influenza A Virus Assembly and Release" @default.
• W4385767047 cites W1130884682 @default.
• W4385767047 cites W1501087097 @default.
• W4385767047 cites W1538591251 @default.
• W4385767047 cites W1911558478 @default.
• W4385767047 cites W1989368177 @default.
• W4385767047 cites W1990545448 @default.
• W4385767047 cites W2002632348 @default.
• W4385767047 cites W2008862638 @default.
• W4385767047 cites W2016244758 @default.
• W4385767047 cites W2028372889 @default.
• W4385767047 cites W2030662368 @default.
• W4385767047 cites W2031080323 @default.
• W4385767047 cites W2040883346 @default.
• W4385767047 cites W2042469110 @default.
• W4385767047 cites W2046182783 @default.
• W4385767047 cites W2059435741 @default.
• W4385767047 cites W2069124418 @default.
• W4385767047 cites W2074712481 @default.
• W4385767047 cites W2077219861 @default.
• W4385767047 cites W2093485136 @default.
• W4385767047 cites W2104589227 @default.
• W4385767047 cites W2107723887 @default.
• W4385767047 cites W2108791168 @default.
• W4385767047 cites W2120646408 @default.
• W4385767047 cites W2133106116 @default.
• W4385767047 cites W2140862281 @default.
• W4385767047 cites W2147783541 @default.
• W4385767047 cites W2149850870 @default.
• W4385767047 cites W2150661836 @default.
• W4385767047 cites W2160139405 @default.
• W4385767047 cites W2160578795 @default.
• W4385767047 cites W2161053460 @default.
• W4385767047 cites W2161496722 @default.
• W4385767047 cites W2163135112 @default.
• W4385767047 cites W2163513953 @default.
• W4385767047 cites W2262968576 @default.
• W4385767047 cites W2265060724 @default.
• W4385767047 cites W2491683774 @default.
• W4385767047 cites W2743828285 @default.
• W4385767047 cites W2762703589 @default.
• W4385767047 cites W2771904066 @default.
• W4385767047 cites W2795794761 @default.
• W4385767047 cites W2810353019 @default.
• W4385767047 cites W2888334095 @default.
• W4385767047 cites W2890790004 @default.
• W4385767047 cites W2895833695 @default.
• W4385767047 cites W2898721059 @default.
• W4385767047 cites W2904615123 @default.
• W4385767047 cites W2919790473 @default.
• W4385767047 cites W2945681432 @default.
• W4385767047 cites W2945953636 @default.
• W4385767047 cites W2951079315 @default.
• W4385767047 cites W2952224970 @default.
• W4385767047 cites W2981536928 @default.
• W4385767047 cites W2990179039 @default.
• W4385767047 cites W3111381237 @default.
• W4385767047 cites W3136082022 @default.
• W4385767047 cites W3137000280 @default.
• W4385767047 cites W3164201895 @default.
• W4385767047 cites W3194867376 @default.
• W4385767047 cites W3196164980 @default.
• W4385767047 cites W3205589531 @default.
• W4385767047 cites W4200403158 @default.
• W4385767047 cites W4210584990 @default.
• W4385767047 cites W4230654908 @default.
• W4385767047 cites W4280587426 @default.
• W4385767047 cites W4366463368 @default.
• W4385767047 cites W4367314884 @default.
• W4385767047 doi "https://doi.org/10.1101/2023.08.08.552198" @default.
• W4385767047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37609131" @default.
• W4385767047 hasPublicationYear "2023" @default.
• W4385767047 type Work @default.
• W4385767047 citedByCount "0" @default.
• W4385767047 crossrefType "posted-content" @default.
• W4385767047 hasAuthorship W4385767047A5006689364 @default.
• W4385767047 hasAuthorship W4385767047A5041296481 @default.
• W4385767047 hasAuthorship W4385767047A5041350430 @default.
• W4385767047 hasAuthorship W4385767047A5045739357 @default.
• W4385767047 hasAuthorship W4385767047A5088268527 @default.
• W4385767047 hasBestOaLocation W43857670471 @default.
• W4385767047 hasConcept C134164806 @default.
• W4385767047 hasConcept C140704245 @default.
• W4385767047 hasConcept C159047783 @default.
• W4385767047 hasConcept C159654299 @default.
• W4385767047 hasConcept C203014093 @default.
• W4385767047 hasConcept C2522874641 @default.
• W4385767047 hasConcept C2777546802 @default.
• W4385767047 hasConcept C2778692840 @default.
• W4385767047 hasConcept C542903549 @default.
• W4385767047 hasConcept C58475186 @default.

• next