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- W4385769149 abstract "Abstract Electroconvulsive therapy (ECT) is the most effective psychiatric treatment but the underlying mechanisms are still unclear. In vivo human magnetic resonance imaging (MRI) studies have consistently reported ECT-induced transient hippocampal volume increases, and an animal model of ECT (electroconvulsive stimulation: ECS) was shown to increase neurogenesis. However, a causal relationship between neurogenesis and MRI-detectable hippocampal volume increases following ECT has not been verified. In this study, we were randomly allocated into four groups, each undergoing a different number of ECS sessions (e.g., 0, 3, 6, 9). T2-weighted image was acquired from those mice using 11.7-tesla MRI. A whole brain voxel-based morphometry analysis was conducted to identify any ECS-induced brain volume changes. Additionally, histological examinations with super-resolution microscopy were conducted to investigate microstructural changes in brain regions which show volume changes following ECS. Furthermore, parallel experiments were performed on X-ray irradiated mice to investigate a causal relationship between neurogenesis and ECS-related volume changes. As a result, we revealed for the first time that ECS induced MRI-detectable dose-dependent hippocampal volume increase in mice. Furthermore, ECS increased hippocampal volumes even in mice lacking neurogenesis, suggesting that neurogenesis is not required for the increase. Comprehensive histological analyses identified an increase in excitatory synaptic density in the ventral CA1 as a major contributor to the observed hippocampal volume increase following ECS. Our findings demonstrate that modification of synaptic structures rather than neurogenesis may be the underlying biological mechanism of ECT/ECS-induced hippocampal volume increase." @default.
- W4385769149 created "2023-08-12" @default.
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- W4385769149 date "2023-08-11" @default.
- W4385769149 modified "2023-10-18" @default.
- W4385769149 title "Neurogenesis-independent mechanisms of MRI-detectable hippocampal volume increase following electroconvulsive stimulation" @default.
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- W4385769149 doi "https://doi.org/10.21203/rs.3.rs-3215270/v1" @default.
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