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- W4385771034 abstract "Colorectal cancer (CRC) is the fourth cause of cancer-related death worldwide. The prognosis is still poor, particularly in metastatic-stage cases. The combination of chemotherapy with immunotherapy to target the dysregulated proteins, such as epidermal growth factor receptor and VEGFR, is found effective for metastatic CRC (mCRC) patients. Researchers are now developing personalized medicines by validating key biomarkers to understand the mechanism of drug resistance and toxicity. The objective of this chapter is to give a comprehensive overview of the current landscape of targetable oncogenic alterations in mCRC. Future areas of research focusing on systemic therapy of CRC are highlighted." @default.
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- W4385771034 date "2023-01-01" @default.
- W4385771034 modified "2023-09-26" @default.
- W4385771034 title "Colorectal cancer heterogeneity and targeted therapy: clinical implications, challenges, and solutions for treatment resistance" @default.
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- W4385771034 doi "https://doi.org/10.1016/b978-0-443-16034-9.00005-8" @default.
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