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- W4385773913 abstract "Cells often alter metabolic strategies under nutrient-deprived conditions to support their survival and growth. Characterizing metabolic reprogramming in the tumor microenvironment (TME) is of emerging importance in cancer research and patient care. However, recent technologies only measure a subset of metabolites and cannot provide in situ measurements. Computational methods such as flux balance analysis (FBA) have been developed to estimate metabolic flux from bulk RNA-seq data and can potentially be extended to single-cell RNA-seq (scRNA-seq) data. However, it is unclear how reliable current methods are, particularly in TME characterization. Here, we present a computational framework METAFlux (METAbolic Flux balance analysis) to infer metabolic fluxes from bulk or single-cell transcriptomic data. Large-scale experiments using cell-lines, the cancer genome atlas (TCGA), and scRNA-seq data obtained from diverse cancer and immunotherapeutic contexts, including CAR-NK cell therapy, have validated METAFlux's capability to characterize metabolic heterogeneity and metabolic interaction amongst cell types." @default.
- W4385773913 created "2023-08-12" @default.
- W4385773913 creator A5007160108 @default.
- W4385773913 creator A5007244861 @default.
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- W4385773913 creator A5084018853 @default.
- W4385773913 date "2023-08-12" @default.
- W4385773913 modified "2023-09-29" @default.
- W4385773913 title "Characterizing cancer metabolism from bulk and single-cell RNA-seq data using METAFlux" @default.
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