FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385777555> ?p ?o ?g. }

• W4385777555 endingPage "110667" @default.
• W4385777555 startingPage "110667" @default.
• W4385777555 abstract "Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. The development of inhibitors for these enzymes has been the focus for the treatment of several conditions, such as Alzheimer's disease. Novel chemical entities are evaluated as potential inhibitors of AChE and BChE using enzyme kinetics. A common issue encountered in these studies is low aqueous solubility of the possible inhibitor. Additives such as cosolvents or detergents can be included in these studies improve the aqueous solubility. Typical cosolvents include acetonitrile or dimethyl sulfoxide while typical detergents include Polysorbate 20 (Tween 20) or 3-((3-cholamidopropyl) dimethylammonio)-1-propanesulfonate (CHAPS). When solubility is not improved, these molecules are often not evaluated further. To address this issue eleven cosolvents and six detergents that could facilitate aqueous solubility were evaluated to understand how they would affect cholinesterase enzymes using Ellman's assay. These studies show that propylene glycol, acetonitrile, methanol, Tween 20, Polysorbate 80 (Tween 80), polyoxyethylene 23 lauryl ether (Brij 35) and polyoxyethylene 10 oleoyl ether (Brij 96v) have the least inhibitory effects towards cholinesterase activity. It is concluded that these cosolvents and detergents should be considered as solubilizing agents for evaluation of potential cholinesterase inhibitors with low aqueous solubility." @default.
• W4385777555 created "2023-08-13" @default.
• W4385777555 creator A5008278069 @default.
• W4385777555 creator A5018130591 @default.
• W4385777555 creator A5023188629 @default.
• W4385777555 creator A5036896222 @default.
• W4385777555 creator A5075215178 @default.
• W4385777555 date "2023-09-01" @default.
• W4385777555 modified "2023-10-17" @default.
• W4385777555 title "Solvents and detergents compatible with enzyme kinetic studies of cholinesterases" @default.
• W4385777555 cites W1484089182 @default.
• W4385777555 cites W1759290616 @default.
• W4385777555 cites W1964706579 @default.
• W4385777555 cites W1969690495 @default.
• W4385777555 cites W1971048984 @default.
• W4385777555 cites W1994067502 @default.
• W4385777555 cites W1994792253 @default.
• W4385777555 cites W1999197232 @default.
• W4385777555 cites W2018992351 @default.
• W4385777555 cites W2028799814 @default.
• W4385777555 cites W2034636268 @default.
• W4385777555 cites W2035709988 @default.
• W4385777555 cites W2038474702 @default.
• W4385777555 cites W2057636248 @default.
• W4385777555 cites W2059472446 @default.
• W4385777555 cites W2062239921 @default.
• W4385777555 cites W2068265873 @default.
• W4385777555 cites W2072295461 @default.
• W4385777555 cites W2072688677 @default.
• W4385777555 cites W2085907924 @default.
• W4385777555 cites W2088399011 @default.
• W4385777555 cites W2090663532 @default.
• W4385777555 cites W2101472522 @default.
• W4385777555 cites W2104227586 @default.
• W4385777555 cites W2107740251 @default.
• W4385777555 cites W2191716201 @default.
• W4385777555 cites W2278818539 @default.
• W4385777555 cites W2590262145 @default.
• W4385777555 cites W2761996428 @default.
• W4385777555 cites W2795438215 @default.
• W4385777555 cites W2796303051 @default.
• W4385777555 cites W2972464215 @default.
• W4385777555 cites W2976163884 @default.
• W4385777555 cites W2995252331 @default.
• W4385777555 cites W3048377477 @default.
• W4385777555 cites W3099508421 @default.
• W4385777555 cites W3134789971 @default.
• W4385777555 cites W3160372749 @default.
• W4385777555 cites W4220993307 @default.
• W4385777555 cites W4283649765 @default.
• W4385777555 cites W4324309277 @default.
• W4385777555 cites W4382136890 @default.
• W4385777555 doi "https://doi.org/10.1016/j.cbi.2023.110667" @default.
• W4385777555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37579937" @default.
• W4385777555 hasPublicationYear "2023" @default.
• W4385777555 type Work @default.
• W4385777555 citedByCount "0" @default.
• W4385777555 crossrefType "journal-article" @default.
• W4385777555 hasAuthorship W4385777555A5008278069 @default.
• W4385777555 hasAuthorship W4385777555A5018130591 @default.
• W4385777555 hasAuthorship W4385777555A5023188629 @default.
• W4385777555 hasAuthorship W4385777555A5036896222 @default.
• W4385777555 hasAuthorship W4385777555A5075215178 @default.
• W4385777555 hasConcept C155574463 @default.
• W4385777555 hasConcept C178790620 @default.
• W4385777555 hasConcept C181199279 @default.
• W4385777555 hasConcept C184651966 @default.
• W4385777555 hasConcept C185592680 @default.
• W4385777555 hasConcept C2777897440 @default.
• W4385777555 hasConcept C2778452553 @default.
• W4385777555 hasConcept C2778816929 @default.
• W4385777555 hasConcept C2779059548 @default.
• W4385777555 hasConcept C2779101902 @default.
• W4385777555 hasConcept C31896038 @default.
• W4385777555 hasConcept C43617362 @default.
• W4385777555 hasConcept C55493867 @default.
• W4385777555 hasConcept C58226133 @default.
• W4385777555 hasConcept C71924100 @default.
• W4385777555 hasConcept C94412978 @default.
• W4385777555 hasConcept C98274493 @default.
• W4385777555 hasConceptScore W4385777555C155574463 @default.
• W4385777555 hasConceptScore W4385777555C178790620 @default.
• W4385777555 hasConceptScore W4385777555C181199279 @default.
• W4385777555 hasConceptScore W4385777555C184651966 @default.
• W4385777555 hasConceptScore W4385777555C185592680 @default.
• W4385777555 hasConceptScore W4385777555C2777897440 @default.
• W4385777555 hasConceptScore W4385777555C2778452553 @default.
• W4385777555 hasConceptScore W4385777555C2778816929 @default.
• W4385777555 hasConceptScore W4385777555C2779059548 @default.
• W4385777555 hasConceptScore W4385777555C2779101902 @default.
• W4385777555 hasConceptScore W4385777555C31896038 @default.
• W4385777555 hasConceptScore W4385777555C43617362 @default.
• W4385777555 hasConceptScore W4385777555C55493867 @default.
• W4385777555 hasConceptScore W4385777555C58226133 @default.
• W4385777555 hasConceptScore W4385777555C71924100 @default.
• W4385777555 hasConceptScore W4385777555C94412978 @default.
• W4385777555 hasConceptScore W4385777555C98274493 @default.
• W4385777555 hasFunder F4320309985 @default.

• next