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- W4385777700 abstract "Hemophagocytic lymphohistiocytosis (HLH) is a devastating disorder of uncontrolled immune activation characterized by clinical and laboratory evidence of extreme inflammation, occurring either as a familial or a secondary HLH, which is acquired in association with a variety of pathological states.[1] In recent years, HLH has attracted growing attention due to an inexplicable rise in the interest of physicians in recognizing and reporting the disorder. Clinical features may vary from a typical presentation with fever, cytopenia, hepatosplenomegaly to atypical complications such as rash, hepatitis or acute liver failure, coagulopathy, and central nervous system (CNS) involvement, which manifest as an altered mental status, seizures, and focal deficits.[2] Unfortunately, the diagnosis of HLH is often delayed due to the intricacies of the established diagnostic criteria[1] of this deadly disease, which leads to irony as HLH needs a very fast and accurate diagnosis to prevent mortality. It is also worthy to be aware of the fact that diagnosis of HLH does not fundamentally depend upon morphological findings of hemophagocytosis as it can be absent in the early stages of the disease. Hence, it would be wise to perform serial bone marrow aspirations later in the course of the disease if the clinical suspicion is very high.[3]" @default.
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- W4385777700 date "2023-08-12" @default.
- W4385777700 modified "2023-10-16" @default.
- W4385777700 title "Hemophagocytic Lymphohistiocytosis (HLH): A Rare Cause of Primary Engraftment Failure Post Autologous Stem Cell Transplant" @default.
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- W4385777700 doi "https://doi.org/10.1055/s-0042-1748183" @default.
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