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• W4385777725 startingPage "104594" @default.
• W4385777725 abstract "Retinal hemodynamics and biomechanics play a significant role in understanding the pathophysiology of several ocular diseases. However, these parameters are significantly affected due to changed blood vessel morphology ascribed to pathological conditions, particularly diabetes. In this study, an image-based computational fluid dynamics (CFD) model is applied to examine the effects of changed vascular morphology due to diabetes on blood flow velocity, vorticity, wall shear stress (WSS), and oxygen distribution and compare it with healthy. The 3D patient-specific vascular architecture of diabetic and healthy retina is extracted from Optical Coherence Tomography Angiography (OCTA) images and fundus to extract the capillary level information. Further, Fluid-structure interaction (FSI) simulations have been performed to compare the induced tissue stresses in diabetic and healthy conditions. Results illustrate that most arterioles possess higher velocity, vorticity, WSS, and lesser oxygen concentration than arteries for healthy and diabetic cases. However, an opposite trend is observed for venules and veins. Comparisons show that, on average, the blood flow velocity in the healthy case decreases by 42 % in arteries and 21 % in veins, respectively, compared to diabetic. In addition, the WSS and von Mises stress (VMS) in healthy case decrease by 49 % and 72 % in arteries and by 6 % and 28 % in veins, respectively, when compared with diabetic, making diabetic blood vessels more susceptible to wall rupture and tissue damage. The in-silico results may help predict the possible abnormalities region early, helping the ophthalmologists use these estimates as prognostic tools and tailor patient-specific treatment plans." @default.
• W4385777725 created "2023-08-13" @default.
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• W4385777725 date "2023-11-01" @default.
• W4385777725 modified "2023-10-17" @default.
• W4385777725 title "Image-based insilico investigation of hemodynamics and biomechanics in healthy and diabetic human retinas" @default.
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• W4385777725 doi "https://doi.org/10.1016/j.mvr.2023.104594" @default.
• W4385777725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37579814" @default.
• W4385777725 hasPublicationYear "2023" @default.
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