Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385778826> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4385778826 endingPage "50" @default.
- W4385778826 startingPage "44" @default.
- W4385778826 abstract "Cutaneous melanoma is a highly aggressive and malignant skin cancer, and its high recurrence rate and drug resistance increase the difficulty of treating advanced-stage patients. Studies have revealed that treatment via stimulation of alpha-1 adrenergic receptor (ADRA1) subtypes inhibits melanoma growth in mice. However, the associations between alpha-1D adrenergic receptor (ADRA1D) and cutaneous melanoma are poorly understood. Tissue specimens from 16 pairs of patients with a pigmented nevus and cutaneous melanoma were analyzed for ADRA1D expression using immunohistochemical staining. Western blotting and RT-qPCR were carried out in order to detect ADRA1D expression levels in melanoma cells and human epidermal melanocytes (HEMs), hypoxia-inducible factor-1α (HIF-1α), and vascular endothelial growth factor (VEGF) levels in HUVECS. A375 cells were transfected with a lentivirus overexpressing ADRA1D. Wound-healing, Transwell, and cell proliferation assays were utilized to identify the ADRA1D effect on the migration, invasion, and proliferation of the two groups of A375 cells in vitro. In order to evaluate the function of ADRA1D in vivo, a melanoma xenograft model was developed in immunodeficient mice. ADRA1D was low expressed in cutaneous melanoma tissues. Overexpression of ADRA1D inhibited the tubulation and migration of HUVECs in vitro. Overexpression of ADRA1D significantly decreased the HIF-1α and VEGF expression. Overexpression of ADRA1D inhibited the invasion and proliferation of A375 melanoma cells in vitro and reduced its angiogenesis in vivo. ADRA1D inhibits cutaneous melanoma growth and angiogenesis. It attenuates melanoma cell proliferation and invasion. Meanwhile, its anti-angiogenic effect is achieved by negatively regulating the HIF-1α/VEGF axis in melanoma tissue, thereby attenuating the growth of cutaneous melanoma and reducing the potential of metastasis." @default.
- W4385778826 created "2023-08-13" @default.
- W4385778826 creator A5025528695 @default.
- W4385778826 creator A5034848206 @default.
- W4385778826 creator A5037501161 @default.
- W4385778826 creator A5038145110 @default.
- W4385778826 creator A5046354867 @default.
- W4385778826 creator A5092632694 @default.
- W4385778826 date "2023-05-31" @default.
- W4385778826 modified "2023-09-25" @default.
- W4385778826 title "Functional involvement of ADRA1D in cutaneous melanoma progression and angiogenesis" @default.
- W4385778826 doi "https://doi.org/10.14715/cmb/2023.69.5.8" @default.
- W4385778826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37571902" @default.
- W4385778826 hasPublicationYear "2023" @default.
- W4385778826 type Work @default.
- W4385778826 citedByCount "0" @default.
- W4385778826 crossrefType "journal-article" @default.
- W4385778826 hasAuthorship W4385778826A5025528695 @default.
- W4385778826 hasAuthorship W4385778826A5034848206 @default.
- W4385778826 hasAuthorship W4385778826A5037501161 @default.
- W4385778826 hasAuthorship W4385778826A5038145110 @default.
- W4385778826 hasAuthorship W4385778826A5046354867 @default.
- W4385778826 hasAuthorship W4385778826A5092632694 @default.
- W4385778826 hasBestOaLocation W43857788261 @default.
- W4385778826 hasConcept C142724271 @default.
- W4385778826 hasConcept C150903083 @default.
- W4385778826 hasConcept C167734588 @default.
- W4385778826 hasConcept C203014093 @default.
- W4385778826 hasConcept C207001950 @default.
- W4385778826 hasConcept C2777025900 @default.
- W4385778826 hasConcept C2777658100 @default.
- W4385778826 hasConcept C2780269544 @default.
- W4385778826 hasConcept C2780394083 @default.
- W4385778826 hasConcept C502942594 @default.
- W4385778826 hasConcept C54355233 @default.
- W4385778826 hasConcept C62112901 @default.
- W4385778826 hasConcept C71924100 @default.
- W4385778826 hasConcept C86803240 @default.
- W4385778826 hasConceptScore W4385778826C142724271 @default.
- W4385778826 hasConceptScore W4385778826C150903083 @default.
- W4385778826 hasConceptScore W4385778826C167734588 @default.
- W4385778826 hasConceptScore W4385778826C203014093 @default.
- W4385778826 hasConceptScore W4385778826C207001950 @default.
- W4385778826 hasConceptScore W4385778826C2777025900 @default.
- W4385778826 hasConceptScore W4385778826C2777658100 @default.
- W4385778826 hasConceptScore W4385778826C2780269544 @default.
- W4385778826 hasConceptScore W4385778826C2780394083 @default.
- W4385778826 hasConceptScore W4385778826C502942594 @default.
- W4385778826 hasConceptScore W4385778826C54355233 @default.
- W4385778826 hasConceptScore W4385778826C62112901 @default.
- W4385778826 hasConceptScore W4385778826C71924100 @default.
- W4385778826 hasConceptScore W4385778826C86803240 @default.
- W4385778826 hasIssue "5" @default.
- W4385778826 hasLocation W43857788261 @default.
- W4385778826 hasLocation W43857788262 @default.
- W4385778826 hasOpenAccess W4385778826 @default.
- W4385778826 hasPrimaryLocation W43857788261 @default.
- W4385778826 hasRelatedWork W1613798522 @default.
- W4385778826 hasRelatedWork W2024623214 @default.
- W4385778826 hasRelatedWork W2057131081 @default.
- W4385778826 hasRelatedWork W2077321770 @default.
- W4385778826 hasRelatedWork W2140520381 @default.
- W4385778826 hasRelatedWork W2357263905 @default.
- W4385778826 hasRelatedWork W2890558057 @default.
- W4385778826 hasRelatedWork W2975373816 @default.
- W4385778826 hasRelatedWork W3178515596 @default.
- W4385778826 hasRelatedWork W29305073 @default.
- W4385778826 hasVolume "69" @default.
- W4385778826 isParatext "false" @default.
- W4385778826 isRetracted "false" @default.
- W4385778826 workType "article" @default.