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- W4385778853 endingPage "12453" @default.
- W4385778853 startingPage "12453" @default.
- W4385778853 abstract "Aerobic organisms use molecular oxygen in several reactions, including those in which the oxidation of substrate molecules is coupled to oxygen reduction to produce large amounts of metabolic energy. The utilization of oxygen is associated with the production of ROS, which can damage biological macromolecules but also act as signaling molecules, regulating numerous cellular processes. Mitochondria are the cellular sites where most of the metabolic energy is produced and perform numerous physiological functions by acting as regulatory hubs of cellular metabolism. They retain the remnants of their bacterial ancestors, including an independent genome that encodes part of their protein equipment; they have an accurate quality control system; and control of cellular functions also depends on communication with the nucleus. During aging, mitochondria can undergo dysfunctions, some of which are mediated by ROS. In this review, after a description of how aging affects the mitochondrial quality and quality control system and the involvement of mitochondria in inflammation, we report information on how vitamin E, the main fat-soluble antioxidant, can protect mitochondria from age-related changes. The information in this regard is scarce and limited to some tissues and some aspects of mitochondrial alterations in aging. Improving knowledge of the effects of vitamin E on aging is essential to defining an optimal strategy for healthy aging." @default.
- W4385778853 created "2023-08-13" @default.
- W4385778853 creator A5031330514 @default.
- W4385778853 creator A5066267860 @default.
- W4385778853 creator A5067543686 @default.
- W4385778853 creator A5087006093 @default.
- W4385778853 date "2023-08-05" @default.
- W4385778853 modified "2023-10-16" @default.
- W4385778853 title "Changes in the Mitochondria in the Aging Process—Can α-Tocopherol Affect Them?" @default.
- W4385778853 cites W1233706660 @default.
- W4385778853 cites W1480113445 @default.
- W4385778853 cites W1481432786 @default.
- W4385778853 cites W1490745190 @default.
- W4385778853 cites W1500436940 @default.
- W4385778853 cites W1509408588 @default.
- W4385778853 cites W1524417563 @default.
- W4385778853 cites W1543358981 @default.
- W4385778853 cites W1545350562 @default.
- W4385778853 cites W1576964147 @default.
- W4385778853 cites W1595993343 @default.
- W4385778853 cites W1609102347 @default.
- W4385778853 cites W1734082729 @default.
- W4385778853 cites W1799692929 @default.
- W4385778853 cites W1870776631 @default.
- W4385778853 cites W1893714901 @default.
- W4385778853 cites W1951730546 @default.
- W4385778853 cites W1956327946 @default.
- W4385778853 cites W1963650188 @default.
- W4385778853 cites W1964876127 @default.
- W4385778853 cites W1967465309 @default.
- W4385778853 cites W1967990398 @default.
- W4385778853 cites W1971104692 @default.
- W4385778853 cites W1974485039 @default.
- W4385778853 cites W1974522038 @default.
- W4385778853 cites W1976391651 @default.
- W4385778853 cites W1978631832 @default.
- W4385778853 cites W1981049765 @default.
- W4385778853 cites W1981431290 @default.
- W4385778853 cites W1983400015 @default.
- W4385778853 cites W1985999867 @default.
- W4385778853 cites W1986952822 @default.
- W4385778853 cites W1987442873 @default.
- W4385778853 cites W1989560849 @default.
- W4385778853 cites W1993733276 @default.
- W4385778853 cites W1994501461 @default.
- W4385778853 cites W1995190951 @default.
- W4385778853 cites W1996476919 @default.
- W4385778853 cites W1996813968 @default.
- W4385778853 cites W1997388033 @default.
- W4385778853 cites W1997572777 @default.
- W4385778853 cites W2000730064 @default.
- W4385778853 cites W2000789134 @default.
- W4385778853 cites W2001217576 @default.
- W4385778853 cites W2003066854 @default.
- W4385778853 cites W2003922690 @default.
- W4385778853 cites W2007279445 @default.
- W4385778853 cites W2009902514 @default.
- W4385778853 cites W2018288368 @default.
- W4385778853 cites W2018563185 @default.
- W4385778853 cites W2021786783 @default.
- W4385778853 cites W2027504173 @default.
- W4385778853 cites W2028629615 @default.
- W4385778853 cites W2029857264 @default.
- W4385778853 cites W2030548258 @default.
- W4385778853 cites W2030878603 @default.
- W4385778853 cites W2031568733 @default.
- W4385778853 cites W2032022203 @default.
- W4385778853 cites W2032143273 @default.
- W4385778853 cites W2034087770 @default.
- W4385778853 cites W2035064090 @default.
- W4385778853 cites W2035118435 @default.
- W4385778853 cites W2035232303 @default.
- W4385778853 cites W2036288083 @default.
- W4385778853 cites W2044897807 @default.
- W4385778853 cites W2045364112 @default.
- W4385778853 cites W2048266866 @default.
- W4385778853 cites W2048984899 @default.
- W4385778853 cites W2050063403 @default.
- W4385778853 cites W2052084403 @default.
- W4385778853 cites W2052751736 @default.
- W4385778853 cites W2052889619 @default.
- W4385778853 cites W2053968878 @default.
- W4385778853 cites W2054059225 @default.
- W4385778853 cites W2055709885 @default.
- W4385778853 cites W2056112680 @default.
- W4385778853 cites W2056673369 @default.
- W4385778853 cites W2057983215 @default.
- W4385778853 cites W2058449186 @default.
- W4385778853 cites W2058881502 @default.
- W4385778853 cites W2060811345 @default.
- W4385778853 cites W2062920562 @default.
- W4385778853 cites W2063284227 @default.
- W4385778853 cites W2063669247 @default.
- W4385778853 cites W2064442665 @default.
- W4385778853 cites W2066193715 @default.
- W4385778853 cites W2066223468 @default.
- W4385778853 cites W2067406680 @default.
- W4385778853 cites W2067449732 @default.