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• W4385779894 abstract "The interactions of imatinib (IMA) and erlotinib (ERL) with calf-thymus double-stranded deoxyribonucleic acid (ds-DNA) were studied by using monometallic (Au and Pt) and bimetallic (Au+Pt) nanoparticles modified DNA biosensors. The prepared electrochemical biosensors were designed to show the interaction between IMA (and ERL) and ds-DNA. The characterization of the prepared sensors was carried out by energy-dispersive X-ray spectroscopy (EDX). The influence of Au, Pt, and Au+Pt nanoparticles in the modified biosensor was investigated to elucidate the interaction between the anti-cancer drugs and dsDNA. The interaction was realized based on the electrochemical oxidation signal (at about + 0.80 V) of the guanine (dGu) base of ds-DNA by differential pulse voltammetry (DPV)in pH 4.6 acetate buffer. The effect of the nanoparticle’s concentration and interaction time of IMA (and ERL) with dsDNA on the electrochemical response of dGu were optimized. The results showed that Au+Pt nanoparticles, especially for IMA, significantly affected the binding constant value of the drugs to ds-DNA. Interaction studies have also shown that the binding mode for IMA and ERL could be intercalation and groove binding and the binding constant values were found to be 68.3×106 M-1 and 27.3×107 M-1, respectively." @default.
• W4385779894 created "2023-08-13" @default.
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• W4385779894 date "2023-10-01" @default.
• W4385779894 modified "2023-10-17" @default.
• W4385779894 title "Voltammetric studies on the interaction of ds-DNA with anti-cancer agents imatinib and erlotinib – Comparison of Au and Pt nanoparticle effects to drug-DNA complex formation" @default.
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• W4385779894 doi "https://doi.org/10.1016/j.molliq.2023.122824" @default.
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