Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385780329> ?p ?o ?g. }
- W4385780329 abstract "Abstract The bacterial pathogen Helicobacter pylori , the leading cause of gastric cancer, is genetically highly diverse and harbours a large and variable portfolio of restriction-modification systems. Our understanding of the evolution and function of DNA methylation in bacteria is limited. Here, we performed a comprehensive analysis of the methylome diversity in H. pylori , using a dataset of 541 genomes that included all known phylogeographic populations. The frequency of 96 methyltransferases and the abundance of their cognate recognition sequences were strongly influenced by phylogeographic structure and were inter-correlated, positively or negatively, for 20% of type II methyltransferases. Low density motifs were more likely to be affected by natural selection, as reflected by higher genomic instability and compositional bias. Importantly, direct correlation implied that methylation patterns can be actively enriched by positive selection and suggests that specific sites have important functions in methylation-dependent phenotypes. Finally, we identified lineage-specific selective pressures modulating the contraction and expansion of the motif ACGT, revealing that the genetic load of methylation could be dependent on local ecological factors. Taken together, natural selection may shape both the abundance and distribution of methyltransferases and their specific recognition sequences, likely permitting a fine-tuning of genome-encoded functions not achievable by genetic variation alone." @default.
- W4385780329 created "2023-08-13" @default.
- W4385780329 creator A5037601897 @default.
- W4385780329 creator A5062879070 @default.
- W4385780329 creator A5092368471 @default.
- W4385780329 date "2023-08-12" @default.
- W4385780329 modified "2023-10-14" @default.
- W4385780329 title "Methylome evolution suggests lineage-dependent selection in the gastric pathogen Helicobacter pylori" @default.
- W4385780329 cites W1486676348 @default.
- W4385780329 cites W1605984840 @default.
- W4385780329 cites W1961207309 @default.
- W4385780329 cites W1967134059 @default.
- W4385780329 cites W1969051636 @default.
- W4385780329 cites W1969391774 @default.
- W4385780329 cites W1975631336 @default.
- W4385780329 cites W1976608804 @default.
- W4385780329 cites W1977090386 @default.
- W4385780329 cites W1979731094 @default.
- W4385780329 cites W1991369558 @default.
- W4385780329 cites W1991716343 @default.
- W4385780329 cites W1994682108 @default.
- W4385780329 cites W2000971200 @default.
- W4385780329 cites W2006824446 @default.
- W4385780329 cites W2015449706 @default.
- W4385780329 cites W2019226819 @default.
- W4385780329 cites W2019226901 @default.
- W4385780329 cites W2022948175 @default.
- W4385780329 cites W2034521161 @default.
- W4385780329 cites W2052876262 @default.
- W4385780329 cites W2055043387 @default.
- W4385780329 cites W2055822804 @default.
- W4385780329 cites W2060418270 @default.
- W4385780329 cites W2068010186 @default.
- W4385780329 cites W2068768225 @default.
- W4385780329 cites W2070758851 @default.
- W4385780329 cites W2073365346 @default.
- W4385780329 cites W2077299429 @default.
- W4385780329 cites W2079726617 @default.
- W4385780329 cites W2092454947 @default.
- W4385780329 cites W2095928156 @default.
- W4385780329 cites W2096093282 @default.
- W4385780329 cites W2097360283 @default.
- W4385780329 cites W2099533874 @default.
- W4385780329 cites W2100156069 @default.
- W4385780329 cites W2102619694 @default.
- W4385780329 cites W2103441770 @default.
- W4385780329 cites W2108828818 @default.
- W4385780329 cites W2109117147 @default.
- W4385780329 cites W2111387110 @default.
- W4385780329 cites W2120902911 @default.
- W4385780329 cites W2122673596 @default.
- W4385780329 cites W2125460385 @default.
- W4385780329 cites W2126308420 @default.
- W4385780329 cites W2130063710 @default.
- W4385780329 cites W2130072902 @default.
- W4385780329 cites W2133620956 @default.
- W4385780329 cites W2134982091 @default.
- W4385780329 cites W2139180337 @default.
- W4385780329 cites W2140848003 @default.
- W4385780329 cites W2147839609 @default.
- W4385780329 cites W2149142276 @default.
- W4385780329 cites W2151409320 @default.
- W4385780329 cites W2152900584 @default.
- W4385780329 cites W2156738105 @default.
- W4385780329 cites W2161247547 @default.
- W4385780329 cites W2171434257 @default.
- W4385780329 cites W2178098051 @default.
- W4385780329 cites W2192147836 @default.
- W4385780329 cites W2216000698 @default.
- W4385780329 cites W2220831328 @default.
- W4385780329 cites W2267357833 @default.
- W4385780329 cites W2277705055 @default.
- W4385780329 cites W2581018255 @default.
- W4385780329 cites W2589064986 @default.
- W4385780329 cites W2602907179 @default.
- W4385780329 cites W2609752905 @default.
- W4385780329 cites W2614081736 @default.
- W4385780329 cites W2754068978 @default.
- W4385780329 cites W2765923797 @default.
- W4385780329 cites W2770360918 @default.
- W4385780329 cites W2790439490 @default.
- W4385780329 cites W2791547152 @default.
- W4385780329 cites W2950058632 @default.
- W4385780329 cites W2950247734 @default.
- W4385780329 cites W2993005136 @default.
- W4385780329 cites W3005235420 @default.
- W4385780329 cites W3042718059 @default.
- W4385780329 cites W3081304798 @default.
- W4385780329 cites W3081913397 @default.
- W4385780329 cites W3083412662 @default.
- W4385780329 cites W3091955023 @default.
- W4385780329 cites W3100972794 @default.
- W4385780329 cites W3131055609 @default.
- W4385780329 cites W3133909641 @default.
- W4385780329 cites W3138805093 @default.
- W4385780329 cites W3158333211 @default.
- W4385780329 cites W3166162866 @default.
- W4385780329 cites W3185398769 @default.
- W4385780329 cites W3216071084 @default.
- W4385780329 cites W4232271436 @default.