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- W4385783020 abstract "AbstractIn this study, the catechin structure was modified with Halogen and Nitrogen base at C-6 and C-8 Positions in Ring A. Pharmacokinetic parameters affirm the drug-likeness property of the designed compounds. Molecular Docking was performed for all the compounds towards the myostatin inhibition target (PDB: 3HH2). Such desirable quality of modified Catechin will create a spark in the novel drug discovery using acting as a bioenhancer. As a result, the present research is aimed to offer an overview of the structural simulation of Cl, F, I, NH2, NO2, and Br at C-6 and C-8 positions in A Ring A of Catechin. This preliminary evidence creates an impact on the novelsemi0synthetic drug discovery for the therapeutic management of sarcopenia.Keywords: Catechinhalogennitrogenpharmacokineticsbioinformatics Author contributionsAll authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Sarvesh Sabarathinam. The first draft of the manuscript was written by Sarvesh Sabarathinam and Sanjana Satheesh. All authors read and approved the final manuscript.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThe authors declare that no funds, grants, or other support were received during the preparation of this manuscript." @default.
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- W4385783020 date "2023-08-12" @default.
- W4385783020 modified "2023-10-18" @default.
- W4385783020 title "Drug designing and toxicity screening of halogen and nitrogen-augmented catechin in sarcopenic obesity" @default.
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- W4385783020 doi "https://doi.org/10.1080/14786419.2023.2245536" @default.
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