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- W4385784004 abstract "Anxious individuals consistently fail in controlling emotional behavior, leading to excessive avoidance, a trait that prevents learning through exposure. Although the origin of this failure is unclear, one candidate system involves control of emotional actions, coordinated through lateral frontopolar cortex (FPl) via amygdala and sensorimotor connections. Using structural, functional, and neurochemical evidence, we show how FPl-based emotional action control fails in highly-anxious individuals. Their FPl is overexcitable, as indexed by GABA/glutamate ratio at rest, and receives stronger amygdalofugal projections than non-anxious male participants. Yet, high-anxious individuals fail to recruit FPl during emotional action control, relying instead on dorsolateral and medial prefrontal areas. This functional anatomical shift is proportional to FPl excitability and amygdalofugal projections strength. The findings characterize circuit-level vulnerabilities in anxious individuals, showing that even mild emotional challenges can saturate FPl neural range, leading to a neural bottleneck in the control of emotional action tendencies." @default.
- W4385784004 created "2023-08-13" @default.
- W4385784004 creator A5013511505 @default.
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- W4385784004 creator A5057148412 @default.
- W4385784004 creator A5070024061 @default.
- W4385784004 creator A5087340678 @default.
- W4385784004 date "2023-08-12" @default.
- W4385784004 modified "2023-10-03" @default.
- W4385784004 title "Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex" @default.
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