FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385784080> ?p ?o ?g. }

• W4385784080 abstract "Stress-induced cardiovascular diseases characterized by inflammation are among the leading causes of morbidity and mortality in postmenopausal women worldwide. Estradiol (E2) is known to be cardioprotective via the modulation of inflammatory mediators during stress. But the mechanism is unclear. TNFα, a key player in inflammation, is primarily converted to its active form by 'A Disintegrin and Metalloprotease 17' (ADAM17). We investigated if E2 can regulate ADAM17 during stress. Experiments were performed using female FVB wild-type (WT), C57BL/6 WT, and G protein-coupled estrogen receptor 1 knockout (GPER-1 KO) mice and H9c2 cells. The study revealed a significant increase in cardiac injury and inflammation during isoproterenol (ISO)-induced stress in ovariectomized (OVX) mice. Additionally, ADAM17's membrane content (mADAM17) was remarkably increased in OVX and GPER-1 KO mice during stress. However, in vivo supplementation of E2 significantly reduced cardiac injury, mADAM17, and inflammation. Also, administering G1 (GPER-1 agonist) in mice under stress reduced mADAM17. Further experiments demonstrated that E2, via GPER-1/PI3K pathway, localized ADAM17 at the perinuclear region by normalizing β1AR-Gαs, mediating the switch from β2AR-Gαi to Gαs, and reducing phosphorylated kinases, including p38 MAPKs and ERKs. Thus, using G15 and LY294002 to inhibit GPER-1 and its down signaling molecule, PI3K, respectively, in the presence of E2 during stress resulted in the disappearance of E2's modulatory effect on mADAM17. In vitro knockdown of ADAM17 during stress significantly reduced cardiac injury and inflammation, confirming its significant inflammatory role. These interesting findings provide novel evidence that E2 and G1 are potential therapeutic agents for ADAM17-induced inflammatory diseases associated with postmenopausal females." @default.
• W4385784080 created "2023-08-13" @default.
• W4385784080 creator A5004567113 @default.
• W4385784080 creator A5007447403 @default.
• W4385784080 creator A5022433567 @default.
• W4385784080 creator A5022864972 @default.
• W4385784080 creator A5024509167 @default.
• W4385784080 creator A5035047967 @default.
• W4385784080 creator A5035102096 @default.
• W4385784080 creator A5044218768 @default.
• W4385784080 creator A5062239858 @default.
• W4385784080 creator A5062827886 @default.
• W4385784080 creator A5063193554 @default.
• W4385784080 creator A5081765575 @default.
• W4385784080 creator A5090180535 @default.
• W4385784080 creator A5091503330 @default.
• W4385784080 date "2023-08-12" @default.
• W4385784080 modified "2023-10-16" @default.
• W4385784080 title "Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1/PI3K signaling pathway" @default.
• W4385784080 cites W1966512874 @default.
• W4385784080 cites W1993318146 @default.
• W4385784080 cites W2006819180 @default.
• W4385784080 cites W2025013582 @default.
• W4385784080 cites W2026481841 @default.
• W4385784080 cites W2031890587 @default.
• W4385784080 cites W2036842448 @default.
• W4385784080 cites W2050702976 @default.
• W4385784080 cites W2050775608 @default.
• W4385784080 cites W2055923450 @default.
• W4385784080 cites W2059646575 @default.
• W4385784080 cites W2060551064 @default.
• W4385784080 cites W2061966564 @default.
• W4385784080 cites W2072533524 @default.
• W4385784080 cites W2074881372 @default.
• W4385784080 cites W2079558077 @default.
• W4385784080 cites W2091159054 @default.
• W4385784080 cites W2093175308 @default.
• W4385784080 cites W2142119280 @default.
• W4385784080 cites W2166216650 @default.
• W4385784080 cites W2377616424 @default.
• W4385784080 cites W2606044518 @default.
• W4385784080 cites W2766555412 @default.
• W4385784080 cites W2800845865 @default.
• W4385784080 cites W2808844109 @default.
• W4385784080 cites W2879097257 @default.
• W4385784080 cites W2900479021 @default.
• W4385784080 cites W2903963813 @default.
• W4385784080 cites W2906884822 @default.
• W4385784080 cites W2912649156 @default.
• W4385784080 cites W2914371319 @default.
• W4385784080 cites W2941855960 @default.
• W4385784080 cites W2943293743 @default.
• W4385784080 cites W2963901310 @default.
• W4385784080 cites W3023266462 @default.
• W4385784080 cites W3064958262 @default.
• W4385784080 cites W3109735199 @default.
• W4385784080 cites W3126685276 @default.
• W4385784080 cites W3127610985 @default.
• W4385784080 cites W3168418165 @default.
• W4385784080 cites W3169846135 @default.
• W4385784080 cites W3201723581 @default.
• W4385784080 cites W4200624717 @default.
• W4385784080 cites W4283770683 @default.
• W4385784080 cites W4313857827 @default.
• W4385784080 cites W4315753245 @default.
• W4385784080 cites W4321597199 @default.
• W4385784080 cites W4383554957 @default.
• W4385784080 cites W3153977815 @default.
• W4385784080 doi "https://doi.org/10.1007/s00018-023-04886-6" @default.
• W4385784080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37572114" @default.
• W4385784080 hasPublicationYear "2023" @default.
• W4385784080 type Work @default.
• W4385784080 citedByCount "0" @default.
• W4385784080 crossrefType "journal-article" @default.
• W4385784080 hasAuthorship W4385784080A5004567113 @default.
• W4385784080 hasAuthorship W4385784080A5007447403 @default.
• W4385784080 hasAuthorship W4385784080A5022433567 @default.
• W4385784080 hasAuthorship W4385784080A5022864972 @default.
• W4385784080 hasAuthorship W4385784080A5024509167 @default.
• W4385784080 hasAuthorship W4385784080A5035047967 @default.
• W4385784080 hasAuthorship W4385784080A5035102096 @default.
• W4385784080 hasAuthorship W4385784080A5044218768 @default.
• W4385784080 hasAuthorship W4385784080A5062239858 @default.
• W4385784080 hasAuthorship W4385784080A5062827886 @default.
• W4385784080 hasAuthorship W4385784080A5063193554 @default.
• W4385784080 hasAuthorship W4385784080A5081765575 @default.
• W4385784080 hasAuthorship W4385784080A5090180535 @default.
• W4385784080 hasAuthorship W4385784080A5091503330 @default.
• W4385784080 hasBestOaLocation W43857840801 @default.
• W4385784080 hasConcept C121608353 @default.
• W4385784080 hasConcept C126322002 @default.
• W4385784080 hasConcept C134018914 @default.
• W4385784080 hasConcept C166471694 @default.
• W4385784080 hasConcept C185592680 @default.
• W4385784080 hasConcept C2776914184 @default.
• W4385784080 hasConcept C2777164284 @default.
• W4385784080 hasConcept C530470458 @default.
• W4385784080 hasConcept C62478195 @default.
• W4385784080 hasConcept C71924100 @default.
• W4385784080 hasConcept C8264082 @default.

• next