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• W4385792504 abstract "Abstract Based on our earlier report that cell-free chromatin particles (cfChPs) released from dying cancer cells are potentially oncogenic, we hypothesised that metastases arise as new cancers from the cells of target organs transformed by cfChPs released from dying cancer cells. We intravenously injected MDA-MB-231 human breast cancer cells and A375 human melanoma cells into mice with severe combined immunodeficiency and observed that the cells died upon reaching the lungs, and released cfChPs that accumulated in the lung cell nuclei at 48 h. We detected the activation of 10 hallmarks of cancer and immune checkpoints in lung cells at 72 h, suggesting that the lung cells had rapidly transformed into incipient cancer cells. Metaphase preparations and single-cell clones developed from cell cultures of lung metastases that subsequently developed contained chimeric chromosomes of both mouse and human DNA, and the cells co-expressed both human- and mouse-specific proteins. Intravenous injection of purified cfChPs isolated from radiation-killed MDA-MB-231 cells induced lung metastasis containing chimeric chromosomes and co-expressing proteins, providing direct evidence that cfChPs are involved in metastasis induction. These findings strongly support our hypothesis that metastases arise from the cells of target organs and not from cells derived from the primary tumour." @default.
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• W4385792504 date "2023-08-13" @default.
• W4385792504 modified "2023-10-17" @default.
• W4385792504 title "Metastases arise as new cancers from cells of target organs transformed by cell-free chromatin particles released from dying cancer cells" @default.
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• W4385792504 doi "https://doi.org/10.1101/2023.08.09.552586" @default.
• W4385792504 hasPublicationYear "2023" @default.
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