FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385797856> ?p ?o ?g. }

• W4385797856 abstract "Prior studies have not determined whether the effect of dual antiplatelet therapy (DAPT) cessation on the subsequent risk of major adverse cardiac events (MACE) varies by the choice of P2Y12-inhibitor after acute coronary syndrome (ACS).We performed a prespecified subanalysis of a multicenter, prospective registry of ACS patients discharged on ticagrelor or clopidogrel between 2015 and2019. Nonadherence to DAPT was categorized as physician-guided discontinuation and disruption due to adverse effects, nonadherence, or bleeding. The association between DAPT cessation and 1-year MACE was analyzed using multivariate time-updated Cox models with inverse probability of censoring weighted estimators.Out of 2180 patients, 174 (8.3%) prematurely discontinued DAPT (physician-guided, n=126; disruption, n=48). Nonadherent patients were older and had more comorbidities than those on DAPT. Compared with physician-guided discontinuation, disruption occurred earlier after discharge and was more frequent with ticagrelor than with clopidogrel. In time-varying analysis, DAPT cessation was associated with an increased risk of MACE (adjusted HR, 1.32, 95%CI, 1.10-1.76), largely driven by disruption (adjusted HR, 1.47, 95%CI, 1.22-1.73). There was an exponential increase in MACE risk after DAPT cessation within 90 days after ACS, especially after disruption of ticagrelor compared with clopidogrel (Pinteraction<.001). After adjustment for DAPT duration, this interaction was not statistically significant on the additive scale (relative excess risk due to interaction 0.12, 95%CI,-0.99-1.24).In this all-comers registry, 1 in 12 patients prematurely discontinued DAPT within 1 year after ACS. Compared with physician-recommended discontinuation, disruption resulted in a significantly higher risk of MACE. After adjustment for DAPT duration, this association was not moderated by the choice of P2Y12-inhibitor. Clinical trial registered at ClinicalTrials.gov (Identifier: NCT02500290)." @default.
• W4385797856 created "2023-08-15" @default.
• W4385797856 creator A5006622910 @default.
• W4385797856 creator A5025382877 @default.
• W4385797856 creator A5028630452 @default.
• W4385797856 creator A5031758329 @default.
• W4385797856 creator A5043342047 @default.
• W4385797856 creator A5067258444 @default.
• W4385797856 creator A5073173338 @default.
• W4385797856 creator A5083786032 @default.
• W4385797856 creator A5088159669 @default.
• W4385797856 creator A5092635599 @default.
• W4385797856 creator A5092635600 @default.
• W4385797856 date "2023-09-01" @default.
• W4385797856 modified "2023-10-17" @default.
• W4385797856 title "Nonadherence to ticagrelor versus clopidogrel and clinical outcomes in patients with ACS. Results from the CREA-ARIAM registry" @default.
• W4385797856 cites W1270782799 @default.
• W4385797856 cites W2049791623 @default.
• W4385797856 cites W2052692777 @default.
• W4385797856 cites W2066629760 @default.
• W4385797856 cites W2071066672 @default.
• W4385797856 cites W2077338998 @default.
• W4385797856 cites W2087150869 @default.
• W4385797856 cites W2111622726 @default.
• W4385797856 cites W2122779695 @default.
• W4385797856 cites W2133536883 @default.
• W4385797856 cites W2161055506 @default.
• W4385797856 cites W2302769053 @default.
• W4385797856 cites W2543143993 @default.
• W4385797856 cites W2597042927 @default.
• W4385797856 cites W2751087890 @default.
• W4385797856 cites W2752969904 @default.
• W4385797856 cites W2800664265 @default.
• W4385797856 cites W2806396098 @default.
• W4385797856 cites W2902324956 @default.
• W4385797856 cites W2908058866 @default.
• W4385797856 cites W2910709595 @default.
• W4385797856 cites W2946195567 @default.
• W4385797856 cites W2948109622 @default.
• W4385797856 cites W3000092873 @default.
• W4385797856 cites W3158906546 @default.
• W4385797856 cites W3201757503 @default.
• W4385797856 cites W4213371371 @default.
• W4385797856 cites W4223988391 @default.
• W4385797856 cites W4281761516 @default.
• W4385797856 cites W4293577771 @default.
• W4385797856 doi "https://doi.org/10.1016/j.rec.2023.05.011" @default.
• W4385797856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37573968" @default.
• W4385797856 hasPublicationYear "2023" @default.
• W4385797856 type Work @default.
• W4385797856 citedByCount "0" @default.
• W4385797856 crossrefType "journal-article" @default.
• W4385797856 hasAuthorship W4385797856A5006622910 @default.
• W4385797856 hasAuthorship W4385797856A5025382877 @default.
• W4385797856 hasAuthorship W4385797856A5028630452 @default.
• W4385797856 hasAuthorship W4385797856A5031758329 @default.
• W4385797856 hasAuthorship W4385797856A5043342047 @default.
• W4385797856 hasAuthorship W4385797856A5067258444 @default.
• W4385797856 hasAuthorship W4385797856A5073173338 @default.
• W4385797856 hasAuthorship W4385797856A5083786032 @default.
• W4385797856 hasAuthorship W4385797856A5088159669 @default.
• W4385797856 hasAuthorship W4385797856A5092635599 @default.
• W4385797856 hasAuthorship W4385797856A5092635600 @default.
• W4385797856 hasConcept C126322002 @default.
• W4385797856 hasConcept C164705383 @default.
• W4385797856 hasConcept C194828623 @default.
• W4385797856 hasConcept C2777028646 @default.
• W4385797856 hasConcept C2777698277 @default.
• W4385797856 hasConcept C2777849778 @default.
• W4385797856 hasConcept C2778715236 @default.
• W4385797856 hasConcept C2780400711 @default.
• W4385797856 hasConcept C2780739214 @default.
• W4385797856 hasConcept C2780890252 @default.
• W4385797856 hasConcept C500558357 @default.
• W4385797856 hasConcept C50382708 @default.
• W4385797856 hasConcept C71924100 @default.
• W4385797856 hasConceptScore W4385797856C126322002 @default.
• W4385797856 hasConceptScore W4385797856C164705383 @default.
• W4385797856 hasConceptScore W4385797856C194828623 @default.
• W4385797856 hasConceptScore W4385797856C2777028646 @default.
• W4385797856 hasConceptScore W4385797856C2777698277 @default.
• W4385797856 hasConceptScore W4385797856C2777849778 @default.
• W4385797856 hasConceptScore W4385797856C2778715236 @default.
• W4385797856 hasConceptScore W4385797856C2780400711 @default.
• W4385797856 hasConceptScore W4385797856C2780739214 @default.
• W4385797856 hasConceptScore W4385797856C2780890252 @default.
• W4385797856 hasConceptScore W4385797856C500558357 @default.
• W4385797856 hasConceptScore W4385797856C50382708 @default.
• W4385797856 hasConceptScore W4385797856C71924100 @default.
• W4385797856 hasLocation W43857978561 @default.
• W4385797856 hasLocation W43857978562 @default.
• W4385797856 hasOpenAccess W4385797856 @default.
• W4385797856 hasPrimaryLocation W43857978561 @default.
• W4385797856 hasRelatedWork W2017059309 @default.
• W4385797856 hasRelatedWork W2758265996 @default.
• W4385797856 hasRelatedWork W2885922346 @default.
• W4385797856 hasRelatedWork W2938138790 @default.
• W4385797856 hasRelatedWork W3014888916 @default.
• W4385797856 hasRelatedWork W3165557531 @default.
• W4385797856 hasRelatedWork W3175681275 @default.

• next