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• W4385799100 endingPage "10990" @default.
• W4385799100 startingPage "10959" @default.
• W4385799100 abstract "The Janus kinases (JAKs) are key components of the JAK-STAT signaling pathway and are involved in myriad physiological processes. Though they are the molecular targets of many FDA-approved drugs, these drugs manifest adverse effects due in part to their inhibition of the requisite JAK kinase activity. However, the JAKs uniquely possess an integrated pseudokinase domain (JH2) that regulates the adjacent kinase domain (JH1). The therapeutic targeting of JH2 domains has been less thoroughly explored and may present an avenue to modulate the JAKs without the adverse effects associated with targeting the adjacent JH1 domain. The potential of this strategy was recently demonstrated with the FDA approval of the TYK2 JH2 ligand deucravacitinib for treating plaque psoriasis. In this light, the structure and targetability of the JAK pseudokinases are discussed, in conjunction with the state of development of ligands that bind to these domains." @default.
• W4385799100 created "2023-08-15" @default.
• W4385799100 creator A5051180922 @default.
• W4385799100 creator A5051198596 @default.
• W4385799100 date "2023-08-14" @default.
• W4385799100 modified "2023-09-26" @default.
• W4385799100 title "Progress on the Pharmacological Targeting of Janus Pseudokinases" @default.
• W4385799100 cites W1596544970 @default.
• W4385799100 cites W1757990252 @default.
• W4385799100 cites W1891334654 @default.
• W4385799100 cites W1966913649 @default.
• W4385799100 cites W1966969980 @default.
• W4385799100 cites W1980568348 @default.
• W4385799100 cites W1982346259 @default.
• W4385799100 cites W1982542795 @default.
• W4385799100 cites W1984342091 @default.
• W4385799100 cites W1985588649 @default.
• W4385799100 cites W1991381808 @default.
• W4385799100 cites W1992945955 @default.
• W4385799100 cites W2002782759 @default.
• W4385799100 cites W2006795381 @default.
• W4385799100 cites W2009423060 @default.
• W4385799100 cites W2012408584 @default.
• W4385799100 cites W2014215007 @default.
• W4385799100 cites W2019903301 @default.
• W4385799100 cites W2019931350 @default.
• W4385799100 cites W2020257412 @default.
• W4385799100 cites W2022819740 @default.
• W4385799100 cites W2027482274 @default.
• W4385799100 cites W2029160308 @default.
• W4385799100 cites W2030205108 @default.
• W4385799100 cites W2038705787 @default.
• W4385799100 cites W2040002852 @default.
• W4385799100 cites W2040665228 @default.
• W4385799100 cites W2041881307 @default.
• W4385799100 cites W2042960115 @default.
• W4385799100 cites W2045694062 @default.
• W4385799100 cites W2046133002 @default.
• W4385799100 cites W2048411595 @default.
• W4385799100 cites W2049145190 @default.
• W4385799100 cites W2052615604 @default.
• W4385799100 cites W2057360098 @default.
• W4385799100 cites W2093953283 @default.
• W4385799100 cites W2100772783 @default.
• W4385799100 cites W2102377211 @default.
• W4385799100 cites W2102709092 @default.
• W4385799100 cites W2109113173 @default.
• W4385799100 cites W2114713566 @default.
• W4385799100 cites W2118460316 @default.
• W4385799100 cites W2120408260 @default.
• W4385799100 cites W2121445072 @default.
• W4385799100 cites W2131666890 @default.
• W4385799100 cites W2133196685 @default.
• W4385799100 cites W2141032550 @default.
• W4385799100 cites W2141682274 @default.
• W4385799100 cites W2143556657 @default.
• W4385799100 cites W2144664431 @default.
• W4385799100 cites W2157495123 @default.
• W4385799100 cites W2165765668 @default.
• W4385799100 cites W2167617907 @default.
• W4385799100 cites W2168822202 @default.
• W4385799100 cites W2170169485 @default.
• W4385799100 cites W2176516200 @default.
• W4385799100 cites W2231320375 @default.
• W4385799100 cites W2315545909 @default.
• W4385799100 cites W2344106764 @default.
• W4385799100 cites W2489492919 @default.
• W4385799100 cites W2517550655 @default.
• W4385799100 cites W2530452137 @default.
• W4385799100 cites W2567535755 @default.
• W4385799100 cites W2601742683 @default.
• W4385799100 cites W2615299032 @default.
• W4385799100 cites W2743620408 @default.
• W4385799100 cites W2766194957 @default.
• W4385799100 cites W2767394258 @default.
• W4385799100 cites W2782409491 @default.
• W4385799100 cites W2803339448 @default.
• W4385799100 cites W2886338093 @default.
• W4385799100 cites W2892136519 @default.
• W4385799100 cites W2892635078 @default.
• W4385799100 cites W2903341269 @default.
• W4385799100 cites W2905210710 @default.
• W4385799100 cites W2909275830 @default.
• W4385799100 cites W2911245697 @default.
• W4385799100 cites W2914209107 @default.
• W4385799100 cites W2916037465 @default.
• W4385799100 cites W2916659322 @default.
• W4385799100 cites W2916926950 @default.
• W4385799100 cites W2956179332 @default.
• W4385799100 cites W2962182289 @default.
• W4385799100 cites W2964002548 @default.
• W4385799100 cites W2974522508 @default.
• W4385799100 cites W2979696485 @default.
• W4385799100 cites W2981813473 @default.
• W4385799100 cites W2990792664 @default.
• W4385799100 cites W2995463243 @default.
• W4385799100 cites W2998258401 @default.
• W4385799100 cites W3005420401 @default.

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