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• W4385801819 abstract "Abstract Background Monitoring cortical responses to neuromodulation protocols on preclinical models can elucidate fundamental mechanisms of brain function. Concurrent brain stimulation and imaging is challenging, usually compromising spatiotemporal resolution, accuracy, and versatility. Objective We aimed to (1) develop and characterize a multi-channel transcranial magnetic stimulation (TMS) system with electronic control of neuromodulation parameters in a magnetic resonance imaging (MRI) environment, (2) characterize the interplay between the mTMS system and the MRI recordings, and (3) verify how different TMS pulse orientations evoke distinct muscle responses in an anesthetized rat. Methods The multi-channel TMS system was designed using materials and electromagnetic safety mechanisms for compatibility with a 9.4-T scanner for small-animal MRI. To deliver the stimulation, we created a 2-coil transducer enabling electronic control of the induced electric field orientation in the rat’s brain. The MRI compatibility was verified with a radiofrequency transceiver coil measuring MRI signals and the presence of imaging artifacts due to the stimulation pulses. We also investigated the effect of the multi-channel TMS pulse orientation on the motor responses of an anesthetized rat. Results We showed that the stimulation pulses do not affect the anatomical imaging quality, and imaging signals are disrupted only if recorded before 10 ms after pulse delivery. Without physically rotating the coils, we demonstrated that the rat’s motor responses considerably depended on the E-field orientation. Conclusion Our system enables electronically targeted brain stimulation and neuroimaging, opening a possibility for investigating fundamental mechanisms of network brain functions in healthy animals and preclinical models of neurological disorders." @default.
• W4385801819 created "2023-08-15" @default.
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• W4385801819 date "2023-08-14" @default.
• W4385801819 modified "2023-10-02" @default.
• W4385801819 title "A multi-channel TMS system enabling accurate stimulus orientation control during concurrent ultra-high-field MRI for preclinical applications" @default.
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• W4385801819 doi "https://doi.org/10.1101/2023.08.10.552401" @default.
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