Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385802018> ?p ?o ?g. }
- W4385802018 abstract "ABSTRACT Arterial stiffness is a cardiovascular risk factor and dramatically increases as women transition through menopause. The current study assessed whether a mouse model of menopause increases arterial stiffness in a similar manner to aging, and whether activation of the G protein-coupled estrogen receptor (GPER) could reverse stiffness. Female C57Bl/6J mice were ovariectomized (OVX) at 10 weeks of age or aged to 52 weeks, and some mice were treated with GPER agonists. OVX and aging increased pulse wave velocity to a similar extent independent of changes in blood pressure. Aging increased carotid wall thickness, while OVX increased material stiffness without altering vascular geometry. RNA-Seq analysis revealed that OVX downregulated smooth muscle contractile genes. The enantiomerically pure GPER agonist, LNS8801, reversed stiffness in OVX mice to a greater degree than the racemic agonist G-1. In summary, OVX and aging induced arterial stiffening via potentially different mechanisms. Aging was associated with inward remodeling while OVX induced material stiffness independent of geometry and a loss of the contractile phenotype. This study helps to further our understanding of the impact of menopause on vascular health and identifies LNS8801 as a potential therapy to counteract this detrimental process in women." @default.
- W4385802018 created "2023-08-15" @default.
- W4385802018 creator A5001099577 @default.
- W4385802018 creator A5003145972 @default.
- W4385802018 creator A5009336063 @default.
- W4385802018 creator A5021245152 @default.
- W4385802018 creator A5024930203 @default.
- W4385802018 creator A5030873010 @default.
- W4385802018 creator A5030932964 @default.
- W4385802018 creator A5032865926 @default.
- W4385802018 creator A5053790574 @default.
- W4385802018 creator A5057342771 @default.
- W4385802018 creator A5077038090 @default.
- W4385802018 creator A5077929332 @default.
- W4385802018 date "2023-08-14" @default.
- W4385802018 modified "2023-10-14" @default.
- W4385802018 title "Ovariectomy-Induced Arterial Stiffening Differs from Vascular Aging and is Reversed by GPER Activation" @default.
- W4385802018 cites W1571027240 @default.
- W4385802018 cites W1987928893 @default.
- W4385802018 cites W1990024265 @default.
- W4385802018 cites W1993281353 @default.
- W4385802018 cites W2001114982 @default.
- W4385802018 cites W2006500270 @default.
- W4385802018 cites W2039256946 @default.
- W4385802018 cites W2046002743 @default.
- W4385802018 cites W2052872863 @default.
- W4385802018 cites W2085814830 @default.
- W4385802018 cites W2108125219 @default.
- W4385802018 cites W2110922412 @default.
- W4385802018 cites W2121822802 @default.
- W4385802018 cites W2125914602 @default.
- W4385802018 cites W2126284874 @default.
- W4385802018 cites W2129033842 @default.
- W4385802018 cites W2138650758 @default.
- W4385802018 cites W2144536030 @default.
- W4385802018 cites W2161772172 @default.
- W4385802018 cites W2170433952 @default.
- W4385802018 cites W2207060623 @default.
- W4385802018 cites W2269850420 @default.
- W4385802018 cites W2523677942 @default.
- W4385802018 cites W2531856440 @default.
- W4385802018 cites W2767633551 @default.
- W4385802018 cites W2789491433 @default.
- W4385802018 cites W2884136005 @default.
- W4385802018 cites W2889322279 @default.
- W4385802018 cites W2894244694 @default.
- W4385802018 cites W2910712311 @default.
- W4385802018 cites W2931947540 @default.
- W4385802018 cites W2967409093 @default.
- W4385802018 cites W3003072426 @default.
- W4385802018 cites W3126956649 @default.
- W4385802018 cites W3128343690 @default.
- W4385802018 cites W3181113088 @default.
- W4385802018 cites W3198290615 @default.
- W4385802018 cites W4213015984 @default.
- W4385802018 cites W4240543049 @default.
- W4385802018 cites W4283466458 @default.
- W4385802018 cites W4308026779 @default.
- W4385802018 cites W4316035487 @default.
- W4385802018 cites W4319662085 @default.
- W4385802018 cites W4323356405 @default.
- W4385802018 doi "https://doi.org/10.1101/2023.08.10.552881" @default.
- W4385802018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37645992" @default.
- W4385802018 hasPublicationYear "2023" @default.
- W4385802018 type Work @default.
- W4385802018 citedByCount "0" @default.
- W4385802018 crossrefType "posted-content" @default.
- W4385802018 hasAuthorship W4385802018A5001099577 @default.
- W4385802018 hasAuthorship W4385802018A5003145972 @default.
- W4385802018 hasAuthorship W4385802018A5009336063 @default.
- W4385802018 hasAuthorship W4385802018A5021245152 @default.
- W4385802018 hasAuthorship W4385802018A5024930203 @default.
- W4385802018 hasAuthorship W4385802018A5030873010 @default.
- W4385802018 hasAuthorship W4385802018A5030932964 @default.
- W4385802018 hasAuthorship W4385802018A5032865926 @default.
- W4385802018 hasAuthorship W4385802018A5053790574 @default.
- W4385802018 hasAuthorship W4385802018A5057342771 @default.
- W4385802018 hasAuthorship W4385802018A5077038090 @default.
- W4385802018 hasAuthorship W4385802018A5077929332 @default.
- W4385802018 hasBestOaLocation W43858020181 @default.
- W4385802018 hasConcept C121608353 @default.
- W4385802018 hasConcept C126322002 @default.
- W4385802018 hasConcept C134018914 @default.
- W4385802018 hasConcept C166471694 @default.
- W4385802018 hasConcept C170493617 @default.
- W4385802018 hasConcept C185592680 @default.
- W4385802018 hasConcept C2775850156 @default.
- W4385802018 hasConcept C2777164284 @default.
- W4385802018 hasConcept C2778319312 @default.
- W4385802018 hasConcept C2778562196 @default.
- W4385802018 hasConcept C2778938600 @default.
- W4385802018 hasConcept C2779395532 @default.
- W4385802018 hasConcept C2992686903 @default.
- W4385802018 hasConcept C530470458 @default.
- W4385802018 hasConcept C71924100 @default.
- W4385802018 hasConcept C8264082 @default.
- W4385802018 hasConcept C84393581 @default.
- W4385802018 hasConcept C84606932 @default.
- W4385802018 hasConcept C86803240 @default.
- W4385802018 hasConceptScore W4385802018C121608353 @default.