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- W4385803265 abstract "Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ribosomes in resting lymphocytes in vitro and in vivo elongate at typical rates for mammalian cells. Intriguingly, elongation rates can be increased up to 30% by activation in vivo or fever temperature in vitro. Resting and activated lymphocytes possess abundant monosome populations, most of which actively translate in vivo, while in vitro, nearly all can be stalled prior to activation. Quantitating lymphocyte protein mass and translating ribosomes reveals a paradoxically high ratio of cellular protein to ribosomes insufficient to support their rapid in vivo division, suggesting that the activated lymphocyte proteome in vivo may be generated in an unusual manner. Our findings demonstrate the importance of a global understanding of protein synthesis in lymphocytes and other rapidly dividing immune cells." @default.
- W4385803265 created "2023-08-15" @default.
- W4385803265 date "2023-08-14" @default.
- W4385803265 modified "2023-10-14" @default.
- W4385803265 title "Reviewer #3 (Public Review): Paradox Found: Global Accounting of Lymphocyte Protein Synthesis" @default.
- W4385803265 doi "https://doi.org/10.7554/elife.89015.1.sa0" @default.
- W4385803265 hasPublicationYear "2023" @default.
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