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- W4385803485 abstract "Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino acid changes in TP53 sequences are related to tumorigenesis. The pig without tumours had a wild-type TP53 sequence and a 1-bp deletion in the TP53 sequence that resulted in a premature stop codon. In contrast, the pig with nephroblastoma had 6- and 7-bp deletions in the TP53 sequence, resulting in the absence of two amino acids and a premature stop codon, respectively. Our results indicated that TP53 mutations with truncated amino acids may be related to tumour formation." @default.
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- W4385803485 date "2023-08-14" @default.
- W4385803485 modified "2023-10-15" @default.
- W4385803485 title "Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study" @default.
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- W4385803485 doi "https://doi.org/10.1155/2023/7000858" @default.
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