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- W4385804341 abstract "Inspired by disulfide bonding mediated mucin adhesion, a probiotic delivery carrier with intestinal targeting and mucoadhesion properties is developed. Alginate is thiolated with cysteine and the hydrogel carrier is formed by self-assembling of thiolated alginate (alg-thiol) through disulfide bonding. The alg-thiol hydrogel can effectively protect probiotics against gastric acids and digestive enzymes in the stomach because of the protonation of the carboxyl groups and the survival ratio of probiotics increases about 105 times compared to that of unencapsulated probiotics. Then, deprotonation of the carboxyl groups results in swelling of the alg-thiol hydrogel and spontaneous release of the encapsulated probiotics in the small intestine. After arriving at the colon, the alg-thiol hydrogel quickly degrades under reducing condition, and completely releases rest of the encapsulated probiotics due to disruption of the disulfide bonds." @default.
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- W4385804341 date "2023-12-01" @default.
- W4385804341 modified "2023-10-17" @default.
- W4385804341 title "A bioinspired hydrogel carrier with pH/redox dual responsiveness for effective protection and intestinal targeted delivery of probiotics" @default.
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- W4385804341 doi "https://doi.org/10.1016/j.jfoodeng.2023.111695" @default.
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