FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385810080> ?p ?o ?g. }

• W4385810080 abstract "Abstract The important mechanical parameters and their hierarchy in the growth and folding of the human brain have not been thoroughly understood. In this study, we developed a multiscale mechanical model to investigate how the interplay between initial geometrical undulations, differential tangential growth in the cortical plate, and axonal connectivity form and regulate the folding patterns of the human brain in a hierarchical order. To do so, different growth scenarios with bilayer spherical models that features initial undulations on the cortex and uniform or heterogeneous distribution of axonal fibers in the white matter were developed, statistically analyzed, and validated by the imaging observations. The results showed that the differential tangential growth is the inducer of cortical folding, and in a hierarchal order, high-amplitude initial undulations on the surface and axonal fibers in the substrate regulate the folding patterns and determine the location of gyri and sulci. The locations with dense axonal fibers after folding settle in gyri rather than sulci. The statistical results also indicated that there is a strong correlation between the location of positive (outward) and negative (inward) initial undulations and the locations of gyri and sulci after folding, respectively. In addition, the locations of 3-hinge gyral folds are strongly correlated with the initial positive undulations and locations of dense axonal fibers. As another finding, it was revealed that there is a correlation between the density of axonal fibers and local gyrification index, which has been observed in imaging studies but not yet fundamentally explained. This study is the first step in understanding the linkage between abnormal gyrification (surface morphology) and disruption in connectivity that has been observed in some brain disorders such as Autism Spectrum Disorder. Moreover, the findings of the study directly contribute to the concept of the regularity and variability of folding patterns in individual human brains." @default.
• W4385810080 created "2023-08-15" @default.
• W4385810080 creator A5000371063 @default.
• W4385810080 creator A5024516086 @default.
• W4385810080 creator A5032424732 @default.
• W4385810080 creator A5034697893 @default.
• W4385810080 creator A5065522947 @default.
• W4385810080 creator A5084308247 @default.
• W4385810080 creator A5086402061 @default.
• W4385810080 date "2023-08-14" @default.
• W4385810080 modified "2023-10-16" @default.
• W4385810080 title "Mechanical hierarchy in the formation and modulation of cortical folding patterns" @default.
• W4385810080 cites W106121187 @default.
• W4385810080 cites W119090869 @default.
• W4385810080 cites W1248031621 @default.
• W4385810080 cites W133500241 @default.
• W4385810080 cites W1519576347 @default.
• W4385810080 cites W1520719651 @default.
• W4385810080 cites W1530200100 @default.
• W4385810080 cites W1565650237 @default.
• W4385810080 cites W1588321981 @default.
• W4385810080 cites W1614862794 @default.
• W4385810080 cites W1625782012 @default.
• W4385810080 cites W1803481230 @default.
• W4385810080 cites W1902417499 @default.
• W4385810080 cites W1914229609 @default.
• W4385810080 cites W1957322185 @default.
• W4385810080 cites W1965677814 @default.
• W4385810080 cites W1966369410 @default.
• W4385810080 cites W1970394046 @default.
• W4385810080 cites W1972481426 @default.
• W4385810080 cites W1975562240 @default.
• W4385810080 cites W1980858210 @default.
• W4385810080 cites W1983938996 @default.
• W4385810080 cites W1985169302 @default.
• W4385810080 cites W1988183526 @default.
• W4385810080 cites W1994899724 @default.
• W4385810080 cites W2000396820 @default.
• W4385810080 cites W2002012536 @default.
• W4385810080 cites W2003265283 @default.
• W4385810080 cites W2012101788 @default.
• W4385810080 cites W2016248307 @default.
• W4385810080 cites W2017413754 @default.
• W4385810080 cites W2020504674 @default.
• W4385810080 cites W2022077096 @default.
• W4385810080 cites W2028139321 @default.
• W4385810080 cites W2031110489 @default.
• W4385810080 cites W2037283724 @default.
• W4385810080 cites W2038523703 @default.
• W4385810080 cites W2040245119 @default.
• W4385810080 cites W2041781976 @default.
• W4385810080 cites W2049299727 @default.
• W4385810080 cites W2059619101 @default.
• W4385810080 cites W2063176769 @default.
• W4385810080 cites W2063580873 @default.
• W4385810080 cites W2065835831 @default.
• W4385810080 cites W2065835984 @default.
• W4385810080 cites W2076586842 @default.
• W4385810080 cites W2078370124 @default.
• W4385810080 cites W2082863207 @default.
• W4385810080 cites W2090153386 @default.
• W4385810080 cites W2090801042 @default.
• W4385810080 cites W2095984111 @default.
• W4385810080 cites W2102123871 @default.
• W4385810080 cites W2108642789 @default.
• W4385810080 cites W2113319997 @default.
• W4385810080 cites W2113402909 @default.
• W4385810080 cites W2120761216 @default.
• W4385810080 cites W2121893022 @default.
• W4385810080 cites W2130358104 @default.
• W4385810080 cites W2135789936 @default.
• W4385810080 cites W2136389176 @default.
• W4385810080 cites W2139629216 @default.
• W4385810080 cites W2140573886 @default.
• W4385810080 cites W2142438562 @default.
• W4385810080 cites W2143673089 @default.
• W4385810080 cites W2150357704 @default.
• W4385810080 cites W2161083511 @default.
• W4385810080 cites W2165918816 @default.
• W4385810080 cites W2168905703 @default.
• W4385810080 cites W2171508801 @default.
• W4385810080 cites W2171644252 @default.
• W4385810080 cites W2171742440 @default.
• W4385810080 cites W2197758528 @default.
• W4385810080 cites W2199629854 @default.
• W4385810080 cites W2210537348 @default.
• W4385810080 cites W2261362922 @default.
• W4385810080 cites W2268066624 @default.
• W4385810080 cites W2296621543 @default.
• W4385810080 cites W2308001001 @default.
• W4385810080 cites W2317009739 @default.
• W4385810080 cites W2320580054 @default.
• W4385810080 cites W2321455618 @default.
• W4385810080 cites W2341075137 @default.
• W4385810080 cites W2344409160 @default.
• W4385810080 cites W2417231366 @default.
• W4385810080 cites W2464248834 @default.
• W4385810080 cites W2508457464 @default.
• W4385810080 cites W2519792225 @default.
• W4385810080 cites W2530154497 @default.

• next