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- W4385810101 abstract "Abstract Maternal-fetal interface shares similarities with tumor tissues in terms of immune microenvironment. Normal pregnancy is maintained due to the immunosuppressed state, but pyroptosis induced by MITA can trigger the body's immune response and disrupt the immunosuppressed state of the maternal-fetal interface, leading to abortion. In this study, we explored the role of MITA and TRIM38 in regulating pyroptosis and maintaining the immune tolerance of the maternal-fetal interface during pregnancy. Our findings show that the interaction between MITA and TRIM38 plays a crucial role in maintaining the immunosuppressed state of the maternal-fetal interface. Specifically, we observed that TRIM38-mediated K48 ubiquitination of MITA was higher in M2 macrophages, leading to low expression levels of MITA and thus, inhibiting pyroptosis. Conversely, in M1 macrophages, the ubiquitination of K48 was lower, resulting in higher expression levels of MITA and promoting pyroptosis. Our results also indicated that pyroptosis played a significant role in hindering the transformation of M1 to M2 and maintaining the immunosuppressed state of the maternal-fetal interface. The discoveries presented offer significant understanding into the mechanisms that support the preservation of the immune tolerance microenvironment at the maternal-fetal interface, playing a vital role in ensuring successful pregnancy results." @default.
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- W4385810101 date "2023-08-14" @default.
- W4385810101 modified "2023-10-17" @default.
- W4385810101 title "Investigation into the role of MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface" @default.
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- W4385810101 doi "https://doi.org/10.21203/rs.3.rs-3131504/v1" @default.
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