Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385811507> ?p ?o ?g. }
- W4385811507 endingPage "2615" @default.
- W4385811507 startingPage "2615" @default.
- W4385811507 abstract "Transcription factor Homeobox C8 (HOXC8) is identified as a white adipose gene as revealed by expression profile analysis in fat tissues. However, the specific role of HOXC8 in fat accumulation remains to be identified. This study was designed to reveal the effects of HOXC8 on preadipocyte proliferation and differentiation. We first make clear that the expression of HOXC8 is associated with fat contents in muscles, highlighting a role of HOXC8 in fat accumulation. Next, it is demonstrated that HOXC8 promotes the proliferation and differentiation of preadipocytes through gain- and loss-of-function assays in primary cultured porcine preadipocytes. Then, mechanisms underlying the regulation of HOXC8 on preadipocyte proliferation and differentiation are identified with RNA sequencing, and a number of differentially expressed genes (DEGs) in response to HOXC8 knockdown are identified. The top GO (Gene Ontology) terms enriched by DEGs involved in proliferation and differentiation, respectively, are identical. IL-17 signaling pathway is the common one significantly enriched by DEGs involved in preadipocyte proliferation and differentiation, respectively, indicating its importance in mediating fat accumulation regulated by HOXC8. Additionally, we find that the inhibition of proliferation is one of the main processes during preadipocyte differentiation. The results will contribue to further revealing the mechanisms underlying fat accumulation regulated by HOXC8." @default.
- W4385811507 created "2023-08-15" @default.
- W4385811507 creator A5003986323 @default.
- W4385811507 creator A5029830483 @default.
- W4385811507 creator A5052441498 @default.
- W4385811507 creator A5057249905 @default.
- W4385811507 creator A5057830784 @default.
- W4385811507 creator A5066051739 @default.
- W4385811507 creator A5070775744 @default.
- W4385811507 date "2023-08-14" @default.
- W4385811507 modified "2023-09-25" @default.
- W4385811507 title "Effects of HOXC8 on the Proliferation and Differentiation of Porcine Preadipocytes" @default.
- W4385811507 cites W1983829835 @default.
- W4385811507 cites W1996128188 @default.
- W4385811507 cites W1999649641 @default.
- W4385811507 cites W2001163744 @default.
- W4385811507 cites W2002519246 @default.
- W4385811507 cites W2006163886 @default.
- W4385811507 cites W2036139926 @default.
- W4385811507 cites W2051039956 @default.
- W4385811507 cites W2052709954 @default.
- W4385811507 cites W2055106896 @default.
- W4385811507 cites W2071061433 @default.
- W4385811507 cites W2072939831 @default.
- W4385811507 cites W2078831149 @default.
- W4385811507 cites W2081087321 @default.
- W4385811507 cites W2093838441 @default.
- W4385811507 cites W2094222260 @default.
- W4385811507 cites W2102278945 @default.
- W4385811507 cites W2104005232 @default.
- W4385811507 cites W2105207670 @default.
- W4385811507 cites W2107277218 @default.
- W4385811507 cites W2115340562 @default.
- W4385811507 cites W2120317645 @default.
- W4385811507 cites W2123371309 @default.
- W4385811507 cites W2131918846 @default.
- W4385811507 cites W2136212813 @default.
- W4385811507 cites W2137586531 @default.
- W4385811507 cites W2140886368 @default.
- W4385811507 cites W2141458291 @default.
- W4385811507 cites W2186367624 @default.
- W4385811507 cites W2192080449 @default.
- W4385811507 cites W2301182486 @default.
- W4385811507 cites W2336131014 @default.
- W4385811507 cites W2398852852 @default.
- W4385811507 cites W2419094455 @default.
- W4385811507 cites W2593433356 @default.
- W4385811507 cites W2774072836 @default.
- W4385811507 cites W2776031454 @default.
- W4385811507 cites W2783142330 @default.
- W4385811507 cites W2790918102 @default.
- W4385811507 cites W2986002996 @default.
- W4385811507 cites W2992627194 @default.
- W4385811507 cites W3015840102 @default.
- W4385811507 cites W3037368583 @default.
- W4385811507 cites W3092510258 @default.
- W4385811507 cites W3102603051 @default.
- W4385811507 cites W3216789849 @default.
- W4385811507 cites W4213051929 @default.
- W4385811507 cites W4214706888 @default.
- W4385811507 cites W4281610904 @default.
- W4385811507 cites W4286500383 @default.
- W4385811507 cites W4290546603 @default.
- W4385811507 cites W4295359591 @default.
- W4385811507 cites W4306931910 @default.
- W4385811507 cites W4310804843 @default.
- W4385811507 doi "https://doi.org/10.3390/ani13162615" @default.
- W4385811507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37627406" @default.
- W4385811507 hasPublicationYear "2023" @default.
- W4385811507 type Work @default.
- W4385811507 citedByCount "0" @default.
- W4385811507 crossrefType "journal-article" @default.
- W4385811507 hasAuthorship W4385811507A5003986323 @default.
- W4385811507 hasAuthorship W4385811507A5029830483 @default.
- W4385811507 hasAuthorship W4385811507A5052441498 @default.
- W4385811507 hasAuthorship W4385811507A5057249905 @default.
- W4385811507 hasAuthorship W4385811507A5057830784 @default.
- W4385811507 hasAuthorship W4385811507A5066051739 @default.
- W4385811507 hasAuthorship W4385811507A5070775744 @default.
- W4385811507 hasBestOaLocation W43858115071 @default.
- W4385811507 hasConcept C104317684 @default.
- W4385811507 hasConcept C121587040 @default.
- W4385811507 hasConcept C134018914 @default.
- W4385811507 hasConcept C148738053 @default.
- W4385811507 hasConcept C150194340 @default.
- W4385811507 hasConcept C171089720 @default.
- W4385811507 hasConcept C173396325 @default.
- W4385811507 hasConcept C54355233 @default.
- W4385811507 hasConcept C62112901 @default.
- W4385811507 hasConcept C86339819 @default.
- W4385811507 hasConcept C86803240 @default.
- W4385811507 hasConcept C95444343 @default.
- W4385811507 hasConceptScore W4385811507C104317684 @default.
- W4385811507 hasConceptScore W4385811507C121587040 @default.
- W4385811507 hasConceptScore W4385811507C134018914 @default.
- W4385811507 hasConceptScore W4385811507C148738053 @default.
- W4385811507 hasConceptScore W4385811507C150194340 @default.
- W4385811507 hasConceptScore W4385811507C171089720 @default.