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- W4385814164 endingPage "116896" @default.
- W4385814164 startingPage "116896" @default.
- W4385814164 abstract "Cancer therapy-induced heart injury is a significant concern for cancer patients undergoing chemotherapy, radiotherapy, immunotherapy, and also targeted molecular therapy. The use of these treatments can lead to oxidative stress and cardiomyocyte damage in the heart, which can result in heart failure and other cardiac complications. Experimental studies have revealed that chemotherapy drugs such as doxorubicin and cyclophosphamide can cause severe side effects such as cardiac fibrosis, electrophysiological remodeling, chronic oxidative stress and inflammation, etc., which may increase risk of cardiac disorders and attacks for patients that underwent chemotherapy. Similar consequences may also be observed for patients that undergo radiotherapy for left breast or lung malignancies. Polyphenols, a group of natural compounds with antioxidant and anti-inflammatory properties, have shown the potential in protecting against cancer therapy-induced heart injury. These compounds have been found to reduce oxidative stress, necrosis and apoptosis in the heart, thereby preserving cardiac function. In recent years, nanoparticles loaded with polyphenols have also provided for the delivery of these compounds and increasing their efficacy in different organs. These nanoparticles can improve the bioavailability and efficacy of polyphenols while minimizing their toxicity. This review article summarizes the current understanding of the protective effects of polyphenols and nanoparticles loaded with polyphenols against cancer therapy-induced heart injury. The article discusses the mechanisms by which polyphenols protect the heart, including antioxidant and anti-inflammation abilities. The article also highlights the potential benefits of using nanoparticles for the delivery of polyphenols." @default.
- W4385814164 created "2023-08-15" @default.
- W4385814164 creator A5073404341 @default.
- W4385814164 creator A5078866836 @default.
- W4385814164 date "2023-12-01" @default.
- W4385814164 modified "2023-09-27" @default.
- W4385814164 title "Protection against cancer therapy-induced cardiovascular injury by planed-derived polyphenols and nanomaterials" @default.
- W4385814164 cites W1176298813 @default.
- W4385814164 cites W1526139626 @default.
- W4385814164 cites W1804398254 @default.
- W4385814164 cites W1897167971 @default.
- W4385814164 cites W1958022600 @default.
- W4385814164 cites W1963767930 @default.
- W4385814164 cites W1965759641 @default.
- W4385814164 cites W1969860477 @default.
- W4385814164 cites W1993615940 @default.
- W4385814164 cites W1993631036 @default.
- W4385814164 cites W1994139179 @default.
- W4385814164 cites W1996446044 @default.
- W4385814164 cites W1996855922 @default.
- W4385814164 cites W1997849655 @default.
- W4385814164 cites W1998591071 @default.
- W4385814164 cites W2001641030 @default.
- W4385814164 cites W2002207827 @default.
- W4385814164 cites W2005721941 @default.
- W4385814164 cites W2009175704 @default.
- W4385814164 cites W2010782032 @default.
- W4385814164 cites W2011893748 @default.
- W4385814164 cites W2012753961 @default.
- W4385814164 cites W2018165119 @default.
- W4385814164 cites W2032191548 @default.
- W4385814164 cites W2041100273 @default.
- W4385814164 cites W2042938039 @default.
- W4385814164 cites W2043632250 @default.
- W4385814164 cites W2051742647 @default.
- W4385814164 cites W2055037481 @default.
- W4385814164 cites W2055232044 @default.
- W4385814164 cites W2055403266 @default.
- W4385814164 cites W2063250955 @default.
- W4385814164 cites W2063767394 @default.
- W4385814164 cites W2064090537 @default.
- W4385814164 cites W2069179726 @default.
- W4385814164 cites W2069759916 @default.
- W4385814164 cites W2077878390 @default.
- W4385814164 cites W2079916310 @default.
- W4385814164 cites W2084938131 @default.
- W4385814164 cites W2085998534 @default.
- W4385814164 cites W2086335537 @default.
- W4385814164 cites W2102085604 @default.
- W4385814164 cites W2104009986 @default.
- W4385814164 cites W2112674033 @default.
- W4385814164 cites W2115172446 @default.
- W4385814164 cites W2119443549 @default.
- W4385814164 cites W2120130492 @default.
- W4385814164 cites W2126998570 @default.
- W4385814164 cites W2127949779 @default.
- W4385814164 cites W2139246522 @default.
- W4385814164 cites W2140366325 @default.
- W4385814164 cites W2143394958 @default.
- W4385814164 cites W2143485119 @default.
- W4385814164 cites W2151185028 @default.
- W4385814164 cites W2156838976 @default.
- W4385814164 cites W2161352016 @default.
- W4385814164 cites W2161756544 @default.
- W4385814164 cites W2167298849 @default.
- W4385814164 cites W2167985455 @default.
- W4385814164 cites W2168049987 @default.
- W4385814164 cites W2170201161 @default.
- W4385814164 cites W2171185733 @default.
- W4385814164 cites W2177971760 @default.
- W4385814164 cites W2196197543 @default.
- W4385814164 cites W2210778698 @default.
- W4385814164 cites W2214881922 @default.
- W4385814164 cites W2215004999 @default.
- W4385814164 cites W2226816285 @default.
- W4385814164 cites W2229251970 @default.
- W4385814164 cites W2230557600 @default.
- W4385814164 cites W2234413403 @default.
- W4385814164 cites W2257964978 @default.
- W4385814164 cites W2275725646 @default.
- W4385814164 cites W2277879584 @default.
- W4385814164 cites W2279656465 @default.
- W4385814164 cites W2282980403 @default.
- W4385814164 cites W2290771182 @default.
- W4385814164 cites W2296554133 @default.
- W4385814164 cites W2298991506 @default.
- W4385814164 cites W2299099463 @default.
- W4385814164 cites W2301188205 @default.
- W4385814164 cites W2341897351 @default.
- W4385814164 cites W2402118151 @default.
- W4385814164 cites W2408132636 @default.
- W4385814164 cites W2417571213 @default.
- W4385814164 cites W2460646680 @default.
- W4385814164 cites W2462759503 @default.
- W4385814164 cites W2508800546 @default.
- W4385814164 cites W2512085630 @default.
- W4385814164 cites W2519484059 @default.
- W4385814164 cites W2520217702 @default.