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• W4385829294 abstract "The amyloid β peptide aggregates to form extracellular plaques in the brains of Alzheimer’s disease patients. Certain of its fragments have been found to have similar properties to those of the full-length peptide. The best-studied of these is 25-35, which aggregates into fibrils, is toxic to neurons, and forms ion channels in synthetic lipid bilayers. Here, we investigate possible pore-forming structures of oligomers of this peptide in a POPC/POPG membrane. We consider octameric and decameric β-barrels of different topology, strand orientation, and shear, evaluate their stability in an implicit membrane model, and subject the best models to multimicrosecond all-atom molecular dynamics simulations. We find two decameric structures that are kinetically stable in membranes on this time scale: an imperfectly closed antiparallel β-barrel with K28 in the pore lumen and a short parallel β-barrel with K28 toward the membrane interface. Both structures exhibit dehydrated gaps in the pore lumen, which are larger for the antiparallel barrel. Based on these results, the experimental cation selectivity, the dependence of ion channel activity on voltage direction, and certain mutation data, the parallel model seems more compatible with experimental data." @default.
• W4385829294 created "2023-08-16" @default.
• W4385829294 creator A5015988496 @default.
• W4385829294 creator A5032333927 @default.
• W4385829294 creator A5045514460 @default.
• W4385829294 date "2023-08-15" @default.
• W4385829294 modified "2023-09-25" @default.
• W4385829294 title "Putative Pore Structures of Amyloid β 25–35 in Lipid Bilayers" @default.
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• W4385829294 doi "https://doi.org/10.1021/acs.biochem.3c00323" @default.
• W4385829294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37582191" @default.
• W4385829294 hasPublicationYear "2023" @default.
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