FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385830683> ?p ?o ?g. }

• W4385830683 endingPage "115727" @default.
• W4385830683 startingPage "115727" @default.
• W4385830683 abstract "The promising anti-angiogenetic properties of previously synthesized pyrazolyl ureas provided the rationale for the synthesis of novel 5-aminopyrazoles 2–5, differently decorated on the pyrazole nucleus. All the derivatives were tested by MTT assays and proved to be non-cytotoxic against eight different tumor cell lines and normal fibroblasts. An EdU proliferation assay was carried out on human foreskin fibroblasts and VEGF stimulated human umbilical vein endothelial cells which confirmed the absence of cytotoxicity of the compounds on human cells up to 20 μM concentration. To evaluate the influence of the newly synthesized pyrazoles on MAPK and PI3K signaling pathways, the phosphorylation of ERK1/2 and Akt was analyzed by Western blots from HFF and HUVEC cell lysates stimulated with growth factors in the presence or absence of the compounds. Pyrazoles 3b and 3c showed a significant inhibition of Akt phosphorylation in both tested cell lines with lower phosphorylation levels than the reference compound GeGe-3 in HUVEC. Furthermore, derivatives 2 and 3 appeared to strongly affect the migration of HFF cells in a wound healing assay, confirming their potential ability to interfere with the angiogenesis process. The new pyrazole library extends the structure-activity relationships of the previously isolated compounds and highlights the attractiveness of this chemical class for pathological cell migration and angiogenesis." @default.
• W4385830683 created "2023-08-16" @default.
• W4385830683 creator A5006100917 @default.
• W4385830683 creator A5017004109 @default.
• W4385830683 creator A5031515564 @default.
• W4385830683 creator A5045645819 @default.
• W4385830683 creator A5048118855 @default.
• W4385830683 creator A5055289168 @default.
• W4385830683 creator A5064918956 @default.
• W4385830683 creator A5091202892 @default.
• W4385830683 date "2023-11-01" @default.
• W4385830683 modified "2023-10-16" @default.
• W4385830683 title "Novel 5-aminopyrazoles endowed with anti-angiogenetic properties: Design, synthesis and biological evaluation" @default.
• W4385830683 cites W1547736903 @default.
• W4385830683 cites W1963529180 @default.
• W4385830683 cites W1977549744 @default.
• W4385830683 cites W2030172785 @default.
• W4385830683 cites W2050499474 @default.
• W4385830683 cites W2052650545 @default.
• W4385830683 cites W2064460437 @default.
• W4385830683 cites W2075512861 @default.
• W4385830683 cites W2082391135 @default.
• W4385830683 cites W2084575920 @default.
• W4385830683 cites W2094698775 @default.
• W4385830683 cites W2105668062 @default.
• W4385830683 cites W2108921801 @default.
• W4385830683 cites W2119145743 @default.
• W4385830683 cites W2552289982 @default.
• W4385830683 cites W2599010948 @default.
• W4385830683 cites W2637198528 @default.
• W4385830683 cites W2744377419 @default.
• W4385830683 cites W2768178272 @default.
• W4385830683 cites W2774278300 @default.
• W4385830683 cites W2883801207 @default.
• W4385830683 cites W2910003525 @default.
• W4385830683 cites W2919467556 @default.
• W4385830683 cites W2981698053 @default.
• W4385830683 cites W3046170481 @default.
• W4385830683 cites W3088361676 @default.
• W4385830683 cites W3110236576 @default.
• W4385830683 cites W3129369221 @default.
• W4385830683 cites W3160714598 @default.
• W4385830683 cites W3181885635 @default.
• W4385830683 cites W3204788038 @default.
• W4385830683 cites W4200071861 @default.
• W4385830683 cites W4205279585 @default.
• W4385830683 cites W4281663583 @default.
• W4385830683 cites W4296104288 @default.
• W4385830683 cites W4311951524 @default.
• W4385830683 cites W4320035949 @default.
• W4385830683 cites W4322758126 @default.
• W4385830683 cites W4323067022 @default.
• W4385830683 cites W4367053042 @default.
• W4385830683 cites W51564482 @default.
• W4385830683 doi "https://doi.org/10.1016/j.ejmech.2023.115727" @default.
• W4385830683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37597434" @default.
• W4385830683 hasPublicationYear "2023" @default.
• W4385830683 type Work @default.
• W4385830683 citedByCount "0" @default.
• W4385830683 crossrefType "journal-article" @default.
• W4385830683 hasAuthorship W4385830683A5006100917 @default.
• W4385830683 hasAuthorship W4385830683A5017004109 @default.
• W4385830683 hasAuthorship W4385830683A5031515564 @default.
• W4385830683 hasAuthorship W4385830683A5045645819 @default.
• W4385830683 hasAuthorship W4385830683A5048118855 @default.
• W4385830683 hasAuthorship W4385830683A5055289168 @default.
• W4385830683 hasAuthorship W4385830683A5064918956 @default.
• W4385830683 hasAuthorship W4385830683A5091202892 @default.
• W4385830683 hasBestOaLocation W43858306831 @default.
• W4385830683 hasConcept C109316439 @default.
• W4385830683 hasConcept C11960822 @default.
• W4385830683 hasConcept C153911025 @default.
• W4385830683 hasConcept C185592680 @default.
• W4385830683 hasConcept C202751555 @default.
• W4385830683 hasConcept C2777411675 @default.
• W4385830683 hasConcept C2777682936 @default.
• W4385830683 hasConcept C2777834122 @default.
• W4385830683 hasConcept C2780394083 @default.
• W4385830683 hasConcept C2780783641 @default.
• W4385830683 hasConcept C502942594 @default.
• W4385830683 hasConcept C54355233 @default.
• W4385830683 hasConcept C55493867 @default.
• W4385830683 hasConcept C57074206 @default.
• W4385830683 hasConcept C62112901 @default.
• W4385830683 hasConcept C62478195 @default.
• W4385830683 hasConcept C71240020 @default.
• W4385830683 hasConcept C75217442 @default.
• W4385830683 hasConcept C81885089 @default.
• W4385830683 hasConcept C86554907 @default.
• W4385830683 hasConcept C86803240 @default.
• W4385830683 hasConcept C95444343 @default.
• W4385830683 hasConceptScore W4385830683C109316439 @default.
• W4385830683 hasConceptScore W4385830683C11960822 @default.
• W4385830683 hasConceptScore W4385830683C153911025 @default.
• W4385830683 hasConceptScore W4385830683C185592680 @default.
• W4385830683 hasConceptScore W4385830683C202751555 @default.
• W4385830683 hasConceptScore W4385830683C2777411675 @default.
• W4385830683 hasConceptScore W4385830683C2777682936 @default.

• next