FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385837412> ?p ?o ?g. }

• W4385837412 abstract "Abstract Background It is well-established that maintaining stable intraocular pressure (IOP) within the normal range during ophthalmic surgery is important. Esketamine is a commonly used drug in pediatric general anesthesia due to its good analgesic and sedative effects. However, its application in ophthalmic surgery is limited because it can increase IOP. The effect of esketamine combined with other common anesthetics on IOP has been underinvestigated. This study aimed to investigate the effect of different doses of esketamine combined with propofol and sufentanil on IOP during intravenous induction of general anesthesia for pediatric strabismus surgery. Methods A total of 181 children with strabismus undergoing unilateral eye surgery under general anesthesia were recruited. Intravenous induction included the use of sufentanil 0.1 µg/kg, propofol 3 mg/kg, and esketamine. Base on the dosage of esketamine, the patients were randomly allocated into three groups: esketamine low (EL) group with 0.25 mg/kg (n = 62), esketamine high (EH) group with 0.5 mg/kg (n = 60), and normal saline (NS) group (n = 59). Hemodynamic parameters, respiratory parameters, and IOP of the non-surgical eye were recorded and compared among the three groups at different time points: before induction (T 0 ), 1 min after induction but before laryngeal mask insertion (T 1 ), immediately after laryngeal mask insertion (T 2 ), and 2 min after laryngeal mask insertion (T 3 ). Results There were no significant differences in age, gender, body mass index (BMI), and respiratory parameters among the three groups at T 0 . The IOP at T 1 , T 2 , and T 3 was lower than that at T 0 in all three groups. The EH group (12.6 ± 1.6 mmHg) had a significantly higher IOP than the EL group (12.0 ± 1.6 mmHg) and the NS group (11.6 ± 1.7 mmHg) at T 1 . However, no difference was found between the EL and NS groups at any time point. Systolic blood pressure (SBP) and heart rate (HR) at T 1 , T 2 , and T 3 were lower than at baseline, and SBP and HR were higher at T 2 than at T 1 . Additionally, the EH group had a significantly higher HR at T 1 than the other two groups. There was no significant difference in diastolic blood pressure (DBP) among the three groups at any time point. Conclusion Propofol combined with sufentanil significantly decreased IOP during the induction of general anesthesia. Although a dose of 0.5 mg/kg esketamine elevated IOP compared to the low-dose and control groups after induction, the IOP remained lower than baseline. 0.25 mg/kg esketamine combined with propofol and sufentanil had little effect on IOP. Therefore, we advocate that a maximum dose of 0.5 mg/kg esketamine combined with propofol and sufentanil will not elevate IOP compared to baseline in pediatric strabismus surgery. Trial registration The registration number is ChiCTR2200066586 at Chictr.org.cn. Registry on 09/12/2022." @default.
• W4385837412 created "2023-08-16" @default.
• W4385837412 creator A5043226798 @default.
• W4385837412 creator A5058931688 @default.
• W4385837412 creator A5082457024 @default.
• W4385837412 creator A5086461976 @default.
• W4385837412 creator A5087814295 @default.
• W4385837412 date "2023-08-15" @default.
• W4385837412 modified "2023-10-10" @default.
• W4385837412 title "Effect of intravenous induction with different doses of Esketamine combined with propofol and sufentanil on intraocular pressure among pediatric strabismus surgery: a randomized clinical trial" @default.
• W4385837412 cites W1866673877 @default.
• W4385837412 cites W1991373023 @default.
• W4385837412 cites W2022957644 @default.
• W4385837412 cites W2026344480 @default.
• W4385837412 cites W2116514215 @default.
• W4385837412 cites W2277335590 @default.
• W4385837412 cites W2551667140 @default.
• W4385837412 cites W2606135972 @default.
• W4385837412 cites W2943191624 @default.
• W4385837412 cites W2992709942 @default.
• W4385837412 cites W2995530735 @default.
• W4385837412 cites W3041772408 @default.
• W4385837412 cites W3091790607 @default.
• W4385837412 cites W3119210428 @default.
• W4385837412 cites W3127704930 @default.
• W4385837412 cites W3173047265 @default.
• W4385837412 cites W3196483993 @default.
• W4385837412 cites W4220849487 @default.
• W4385837412 cites W4225154573 @default.
• W4385837412 cites W4285490802 @default.
• W4385837412 cites W4290998805 @default.
• W4385837412 cites W4292436051 @default.
• W4385837412 cites W4297905560 @default.
• W4385837412 cites W4360609979 @default.
• W4385837412 cites W4384663661 @default.
• W4385837412 cites W967053570 @default.
• W4385837412 doi "https://doi.org/10.1186/s12871-023-02238-2" @default.
• W4385837412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37582704" @default.
• W4385837412 hasPublicationYear "2023" @default.
• W4385837412 type Work @default.
• W4385837412 citedByCount "0" @default.
• W4385837412 crossrefType "journal-article" @default.
• W4385837412 hasAuthorship W4385837412A5043226798 @default.
• W4385837412 hasAuthorship W4385837412A5058931688 @default.
• W4385837412 hasAuthorship W4385837412A5082457024 @default.
• W4385837412 hasAuthorship W4385837412A5086461976 @default.
• W4385837412 hasAuthorship W4385837412A5087814295 @default.
• W4385837412 hasBestOaLocation W43858374121 @default.
• W4385837412 hasConcept C141071460 @default.
• W4385837412 hasConcept C2776277131 @default.
• W4385837412 hasConcept C2776859179 @default.
• W4385837412 hasConcept C2776864138 @default.
• W4385837412 hasConcept C2777019824 @default.
• W4385837412 hasConcept C2780795376 @default.
• W4385837412 hasConcept C2781092963 @default.
• W4385837412 hasConcept C42219234 @default.
• W4385837412 hasConcept C71924100 @default.
• W4385837412 hasConceptScore W4385837412C141071460 @default.
• W4385837412 hasConceptScore W4385837412C2776277131 @default.
• W4385837412 hasConceptScore W4385837412C2776859179 @default.
• W4385837412 hasConceptScore W4385837412C2776864138 @default.
• W4385837412 hasConceptScore W4385837412C2777019824 @default.
• W4385837412 hasConceptScore W4385837412C2780795376 @default.
• W4385837412 hasConceptScore W4385837412C2781092963 @default.
• W4385837412 hasConceptScore W4385837412C42219234 @default.
• W4385837412 hasConceptScore W4385837412C71924100 @default.
• W4385837412 hasIssue "1" @default.
• W4385837412 hasLocation W43858374121 @default.
• W4385837412 hasLocation W43858374122 @default.
• W4385837412 hasOpenAccess W4385837412 @default.
• W4385837412 hasPrimaryLocation W43858374121 @default.
• W4385837412 hasRelatedWork W1923695179 @default.
• W4385837412 hasRelatedWork W2005225669 @default.
• W4385837412 hasRelatedWork W2038267750 @default.
• W4385837412 hasRelatedWork W2368346630 @default.
• W4385837412 hasRelatedWork W2370764421 @default.
• W4385837412 hasRelatedWork W2982707210 @default.
• W4385837412 hasRelatedWork W3028389065 @default.
• W4385837412 hasRelatedWork W3032216937 @default.
• W4385837412 hasRelatedWork W4206987121 @default.
• W4385837412 hasRelatedWork W2741537073 @default.
• W4385837412 hasVolume "23" @default.
• W4385837412 isParatext "false" @default.
• W4385837412 isRetracted "false" @default.
• W4385837412 workType "article" @default.