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- W4385840277 endingPage "850" @default.
- W4385840277 startingPage "850" @default.
- W4385840277 abstract "Fusarium species are among the filamentous fungi with the most pronounced impact on agricultural production and human health. The mycotoxins produced by pathogenic Fusarium not only attack various plants including crops, causing various plant diseases that lead to reduced yields and even death, but also penetrate into the food chain of humans and animals to cause food poisoning and consequent health hazards. Although sporadic studies have revealed some of the biosynthetic pathways of Fusarium toxins, they are insufficient to satisfy the need for a comprehensive understanding of Fusarium toxin production. In this study, we focused on 35 serious pathogenic Fusarium species with available genomes and systematically analyzed the ubiquity of the distribution of identified Fusarium- and non-Fusarium-derived fungal toxin biosynthesis gene clusters (BGCs) in these species through the mining of core genes and the comparative analysis of corresponding BGCs. Additionally, novel sesterterpene synthases and PKS_NRPS clusters were discovered and analyzed. This work is the first to systematically analyze the distribution of related mycotoxin biosynthesis in pathogenic Fusarium species. These findings enhance the knowledge of mycotoxin production and provide a theoretical grounding for the prevention of fungal toxin production using biotechnological approaches." @default.
- W4385840277 created "2023-08-16" @default.
- W4385840277 creator A5016214793 @default.
- W4385840277 creator A5018073672 @default.
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- W4385840277 creator A5068950959 @default.
- W4385840277 creator A5076625544 @default.
- W4385840277 creator A5087344482 @default.
- W4385840277 date "2023-08-15" @default.
- W4385840277 modified "2023-09-26" @default.
- W4385840277 title "Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in Pathogenic Fusarium" @default.
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