Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385841200> ?p ?o ?g. }
- W4385841200 endingPage "122277" @default.
- W4385841200 startingPage "122277" @default.
- W4385841200 abstract "Intracerebral hemorrhage (ICH) remains the most lethal type of stroke, and effective clinical therapies that can speed up hematoma resolution after ICH are still lacking. While the beneficial effects of IL-10 on ICH recovery have been demonstrated, the clinical translation of IL-10 requires effective delivery methods by which sufficient IL-10 can be delivered to ICH-affected regions in the brain. Here we report the use of a phosphatidylserine (PS) liposome (PSL)-based nanoparticle system for microglia/macrophage-targeted delivery of IL-10 in ICH. We first prepared IL-10-conjugated PSL (PSL-IL10) and characterized their immunomodulating effects in vitro. Then we evaluated the therapeutic effects, including hematoma absorption, short-term outcomes, and neuroinflammation, of intranasally administered PSL-IL10 (3 μg IL-10 per mouse, 2 h post-ICH) in a collagenase-induced ICH mouse model. We also isolated microglia/macrophages from the mouse brains with ICH to analyze their morphology, phagocytosis ability, and polarization. Our study reveals that, 1) PSL-IL10 treatment resulted in significantly improved outcomes and accelerated hematoma resolution in the acute phase of ICH; 2) PSL-IL10 inhibited glial activation and down-regulated pro-inflammatory cytokine production; 3) PSL-IL10 induced Iba1+ cells with a stronger phagocytosis ability; 4) PSL-IL10 activated STAT3 and upregulated CD36 expression in microglia/macrophage. These findings collectively show that PSL-IL10 is a promising nanotherapeutic for effectively ameliorating ICH." @default.
- W4385841200 created "2023-08-16" @default.
- W4385841200 creator A5006130007 @default.
- W4385841200 creator A5045781240 @default.
- W4385841200 creator A5046956458 @default.
- W4385841200 creator A5048398648 @default.
- W4385841200 creator A5052931210 @default.
- W4385841200 creator A5061733937 @default.
- W4385841200 creator A5066359669 @default.
- W4385841200 creator A5070284307 @default.
- W4385841200 creator A5072662743 @default.
- W4385841200 creator A5073398490 @default.
- W4385841200 creator A5075336518 @default.
- W4385841200 creator A5085189717 @default.
- W4385841200 date "2023-10-01" @default.
- W4385841200 modified "2023-10-14" @default.
- W4385841200 title "Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes" @default.
- W4385841200 cites W139494526 @default.
- W4385841200 cites W1486743716 @default.
- W4385841200 cites W1557181127 @default.
- W4385841200 cites W1969437735 @default.
- W4385841200 cites W1979570000 @default.
- W4385841200 cites W2007015540 @default.
- W4385841200 cites W2009373649 @default.
- W4385841200 cites W2028284360 @default.
- W4385841200 cites W2035018608 @default.
- W4385841200 cites W2040176672 @default.
- W4385841200 cites W2042195683 @default.
- W4385841200 cites W2043897018 @default.
- W4385841200 cites W2047543986 @default.
- W4385841200 cites W2053713912 @default.
- W4385841200 cites W2058493730 @default.
- W4385841200 cites W2072203820 @default.
- W4385841200 cites W2090198994 @default.
- W4385841200 cites W2091128689 @default.
- W4385841200 cites W2091142824 @default.
- W4385841200 cites W2092368895 @default.
- W4385841200 cites W2096519700 @default.
- W4385841200 cites W2101798805 @default.
- W4385841200 cites W2104721556 @default.
- W4385841200 cites W2105311419 @default.
- W4385841200 cites W2112161237 @default.
- W4385841200 cites W2115403023 @default.
- W4385841200 cites W2118688515 @default.
- W4385841200 cites W2123301364 @default.
- W4385841200 cites W2143009142 @default.
- W4385841200 cites W2143463421 @default.
- W4385841200 cites W2144613271 @default.
- W4385841200 cites W2165553751 @default.
- W4385841200 cites W2222983484 @default.
- W4385841200 cites W2279979594 @default.
- W4385841200 cites W2336534940 @default.
- W4385841200 cites W2344082772 @default.
- W4385841200 cites W2379226357 @default.
- W4385841200 cites W2471422179 @default.
- W4385841200 cites W2526468060 @default.
- W4385841200 cites W2549191670 @default.
- W4385841200 cites W2556724687 @default.
- W4385841200 cites W2562718103 @default.
- W4385841200 cites W2600321955 @default.
- W4385841200 cites W2603198003 @default.
- W4385841200 cites W2603525527 @default.
- W4385841200 cites W2604481254 @default.
- W4385841200 cites W2615735913 @default.
- W4385841200 cites W2619122250 @default.
- W4385841200 cites W2747375620 @default.
- W4385841200 cites W2765414700 @default.
- W4385841200 cites W2792534994 @default.
- W4385841200 cites W2896500243 @default.
- W4385841200 cites W2898588982 @default.
- W4385841200 cites W2914368780 @default.
- W4385841200 cites W2921324441 @default.
- W4385841200 cites W2931171744 @default.
- W4385841200 cites W2948435134 @default.
- W4385841200 cites W2963100604 @default.
- W4385841200 cites W2980875688 @default.
- W4385841200 cites W2982506976 @default.
- W4385841200 cites W3000213001 @default.
- W4385841200 cites W3004656996 @default.
- W4385841200 cites W3014061270 @default.
- W4385841200 cites W3014670641 @default.
- W4385841200 cites W3015936268 @default.
- W4385841200 cites W3017383527 @default.
- W4385841200 cites W3026586600 @default.
- W4385841200 cites W3031543979 @default.
- W4385841200 cites W3045877203 @default.
- W4385841200 cites W3048428044 @default.
- W4385841200 cites W3094568354 @default.
- W4385841200 cites W3098640872 @default.
- W4385841200 cites W3107220253 @default.
- W4385841200 cites W3107919969 @default.
- W4385841200 cites W3113175786 @default.
- W4385841200 cites W3126678406 @default.
- W4385841200 cites W3129723350 @default.
- W4385841200 cites W3131574368 @default.
- W4385841200 cites W3197233575 @default.
- W4385841200 cites W3208502813 @default.
- W4385841200 cites W4200055115 @default.