FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385841352> ?p ?o ?g. }

• W4385841352 endingPage "102855" @default.
• W4385841352 startingPage "102855" @default.
• W4385841352 abstract "Peroxisomes are metabolically active organelles that are known for exerting oxidative metabolism, but the precise mechanism remains unclear in diabetic nephropathy (DN). Here, we used proteomics to uncover a correlation between the antioxidant protein disulfide-bond A oxidoreductase-like protein (DsbA-L) and peroxisomal function. In vivo, renal tubular injury, oxidative stress, and cell apoptosis in high-fat diet plus streptozotocin (STZ)-induced diabetic mice were significantly increased, and these changes were accompanied by a ghost peroxisomal phenotype, which was further aggravated in DsbA-L-deficient diabetic mice. In vitro, the overexpression of DsbA-L in peroxisomes could improve peroxisomal phenotype and function, reduce oxidative stress and cell apoptosis induced by high glucose (HG, 30 mM) and palmitic acid (PA, 250 μM), but this effect was reversed by 3-Amino-1,2,4-triazole (3-AT, a catalase inhibitor). Mechanistically, DsbA-L regulated the activity of catalase by binding to it, thereby reducing peroxisomal leakage and proteasomal degradation of peroxisomal matrix proteins induced by HG and PA. Additionally, the expression of DsbA-L in renal tubules of patients with DN significantly decreased and was positively correlated with peroxisomal function. Taken together, these results highlight an important role of DsbA-L in ameliorating tubular injury in DN by improving peroxisomal function." @default.
• W4385841352 created "2023-08-16" @default.
• W4385841352 creator A5020306816 @default.
• W4385841352 creator A5021293751 @default.
• W4385841352 creator A5027475930 @default.
• W4385841352 creator A5030494055 @default.
• W4385841352 creator A5038578978 @default.
• W4385841352 creator A5039493947 @default.
• W4385841352 creator A5043061910 @default.
• W4385841352 creator A5051159677 @default.
• W4385841352 creator A5051754049 @default.
• W4385841352 creator A5052583087 @default.
• W4385841352 creator A5053423526 @default.
• W4385841352 creator A5056864536 @default.
• W4385841352 creator A5075647150 @default.
• W4385841352 creator A5085463242 @default.
• W4385841352 creator A5091573005 @default.
• W4385841352 date "2023-10-01" @default.
• W4385841352 modified "2023-10-05" @default.
• W4385841352 title "DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy" @default.
• W4385841352 cites W1984658022 @default.
• W4385841352 cites W1995680796 @default.
• W4385841352 cites W1996141009 @default.
• W4385841352 cites W2002262268 @default.
• W4385841352 cites W2010648114 @default.
• W4385841352 cites W2012540688 @default.
• W4385841352 cites W2039160682 @default.
• W4385841352 cites W2046855853 @default.
• W4385841352 cites W2061712981 @default.
• W4385841352 cites W2066715755 @default.
• W4385841352 cites W2068551753 @default.
• W4385841352 cites W2074580711 @default.
• W4385841352 cites W2078815621 @default.
• W4385841352 cites W2084677632 @default.
• W4385841352 cites W2127998841 @default.
• W4385841352 cites W2132344671 @default.
• W4385841352 cites W2136490577 @default.
• W4385841352 cites W2143538182 @default.
• W4385841352 cites W2156905115 @default.
• W4385841352 cites W2159258864 @default.
• W4385841352 cites W2165723638 @default.
• W4385841352 cites W2167696180 @default.
• W4385841352 cites W2231081458 @default.
• W4385841352 cites W2271842806 @default.
• W4385841352 cites W2338591125 @default.
• W4385841352 cites W2507222891 @default.
• W4385841352 cites W2590277495 @default.
• W4385841352 cites W2603544482 @default.
• W4385841352 cites W2765921352 @default.
• W4385841352 cites W2789251983 @default.
• W4385841352 cites W2789304645 @default.
• W4385841352 cites W2804718062 @default.
• W4385841352 cites W2811227283 @default.
• W4385841352 cites W2915212211 @default.
• W4385841352 cites W2937695541 @default.
• W4385841352 cites W2965179790 @default.
• W4385841352 cites W3011237240 @default.
• W4385841352 cites W3012319668 @default.
• W4385841352 cites W3014696785 @default.
• W4385841352 cites W3027689746 @default.
• W4385841352 cites W3119757928 @default.
• W4385841352 cites W3133173377 @default.
• W4385841352 cites W3156056253 @default.
• W4385841352 cites W3167620345 @default.
• W4385841352 cites W4210831457 @default.
• W4385841352 cites W4220845279 @default.
• W4385841352 cites W4283021278 @default.
• W4385841352 cites W4295196985 @default.
• W4385841352 cites W4319869025 @default.
• W4385841352 doi "https://doi.org/10.1016/j.redox.2023.102855" @default.
• W4385841352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37597421" @default.
• W4385841352 hasPublicationYear "2023" @default.
• W4385841352 type Work @default.
• W4385841352 citedByCount "0" @default.
• W4385841352 crossrefType "journal-article" @default.
• W4385841352 hasAuthorship W4385841352A5020306816 @default.
• W4385841352 hasAuthorship W4385841352A5021293751 @default.
• W4385841352 hasAuthorship W4385841352A5027475930 @default.
• W4385841352 hasAuthorship W4385841352A5030494055 @default.
• W4385841352 hasAuthorship W4385841352A5038578978 @default.
• W4385841352 hasAuthorship W4385841352A5039493947 @default.
• W4385841352 hasAuthorship W4385841352A5043061910 @default.
• W4385841352 hasAuthorship W4385841352A5051159677 @default.
• W4385841352 hasAuthorship W4385841352A5051754049 @default.
• W4385841352 hasAuthorship W4385841352A5052583087 @default.
• W4385841352 hasAuthorship W4385841352A5053423526 @default.
• W4385841352 hasAuthorship W4385841352A5056864536 @default.
• W4385841352 hasAuthorship W4385841352A5075647150 @default.
• W4385841352 hasAuthorship W4385841352A5085463242 @default.
• W4385841352 hasAuthorship W4385841352A5091573005 @default.
• W4385841352 hasBestOaLocation W43858413521 @default.
• W4385841352 hasConcept C127078168 @default.
• W4385841352 hasConcept C170493617 @default.
• W4385841352 hasConcept C185592680 @default.
• W4385841352 hasConcept C2776151105 @default.
• W4385841352 hasConcept C2778979269 @default.
• W4385841352 hasConcept C55493867 @default.
• W4385841352 hasConcept C86803240 @default.

• next