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- W4385841530 endingPage "101150" @default.
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- W4385841530 abstract "The implementation of cancer immunotherapies has seen limited clinical success in head and neck squamous cell carcinoma (HNSCC). Interleukin-2 (IL-2), which modulates the survival and functionality of lymphocytes, is an attractive target for new immunotherapies but one that is limited by presence of regulatory T cells (Tregs) expressing the high-affinity IL-2Rα. The bispecific immunocytokine PD1-IL2v preferentially delivers IL-2 signaling through IL-2Rβγ on PD-1-expressing cells. Selectively targeting the intermediate-affinity IL-2Rβγ can be leveraged to induce anti-tumor immune responses in effector T cells and natural killer (NK) cells while limiting the negative regulation of IL-2Rα activation on Tregs. Using radiation therapy (RT) in combination with PD1-IL2v improves local tumor control and survival, and controls metastatic spread in orthotopic HNSCC tumor models. PD1-IL2v drives systemic activation and expansion of circulating and tumor-infiltrating cytotoxic T cells and NK cells while limiting Treg-mediated immunosuppression. These data show that PD1-L2v induces durable systemic tumor control in HNSCC." @default.
- W4385841530 created "2023-08-16" @default.
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- W4385841530 date "2023-08-01" @default.
- W4385841530 modified "2023-10-14" @default.
- W4385841530 title "Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC" @default.
- W4385841530 cites W1539873584 @default.
- W4385841530 cites W1599507531 @default.
- W4385841530 cites W1697418081 @default.
- W4385841530 cites W1907685339 @default.
- W4385841530 cites W1965194420 @default.
- W4385841530 cites W1972494701 @default.
- W4385841530 cites W1990428948 @default.
- W4385841530 cites W1996235861 @default.
- W4385841530 cites W2003510908 @default.
- W4385841530 cites W2011562061 @default.
- W4385841530 cites W2015776459 @default.
- W4385841530 cites W2033401119 @default.
- W4385841530 cites W2035219486 @default.
- W4385841530 cites W2041953257 @default.
- W4385841530 cites W2044315378 @default.
- W4385841530 cites W2049345643 @default.
- W4385841530 cites W2056535502 @default.
- W4385841530 cites W2064766870 @default.
- W4385841530 cites W2068568648 @default.
- W4385841530 cites W2073300038 @default.
- W4385841530 cites W2097814320 @default.
- W4385841530 cites W2101210424 @default.
- W4385841530 cites W2101354309 @default.
- W4385841530 cites W2111169512 @default.
- W4385841530 cites W2158146964 @default.
- W4385841530 cites W2329107713 @default.
- W4385841530 cites W2329974159 @default.
- W4385841530 cites W2514649790 @default.
- W4385841530 cites W2537963082 @default.
- W4385841530 cites W2557925011 @default.
- W4385841530 cites W2560367415 @default.
- W4385841530 cites W2572174216 @default.
- W4385841530 cites W2572762406 @default.
- W4385841530 cites W2607137647 @default.
- W4385841530 cites W2618283495 @default.
- W4385841530 cites W2619691134 @default.
- W4385841530 cites W2744632602 @default.
- W4385841530 cites W2748446253 @default.
- W4385841530 cites W2749319028 @default.
- W4385841530 cites W2751221763 @default.
- W4385841530 cites W2756061744 @default.
- W4385841530 cites W2761586559 @default.
- W4385841530 cites W2764109170 @default.
- W4385841530 cites W2771542157 @default.
- W4385841530 cites W2804842619 @default.
- W4385841530 cites W2884397271 @default.
- W4385841530 cites W2887723108 @default.
- W4385841530 cites W2914673151 @default.
- W4385841530 cites W2916262950 @default.
- W4385841530 cites W2918589641 @default.
- W4385841530 cites W2920979786 @default.
- W4385841530 cites W2939811893 @default.
- W4385841530 cites W2941582519 @default.
- W4385841530 cites W2965597946 @default.
- W4385841530 cites W2982070380 @default.
- W4385841530 cites W2999410311 @default.
- W4385841530 cites W3007249969 @default.
- W4385841530 cites W3008361765 @default.
- W4385841530 cites W3028149335 @default.
- W4385841530 cites W3028523516 @default.
- W4385841530 cites W3030211068 @default.
- W4385841530 cites W3031374116 @default.
- W4385841530 cites W3031791145 @default.
- W4385841530 cites W3039051942 @default.
- W4385841530 cites W3082205604 @default.
- W4385841530 cites W3082731516 @default.
- W4385841530 cites W3084463400 @default.
- W4385841530 cites W3087181589 @default.
- W4385841530 cites W3098454574 @default.
- W4385841530 cites W3103119004 @default.
- W4385841530 cites W3152586353 @default.
- W4385841530 cites W3162774340 @default.
- W4385841530 cites W3165801055 @default.
- W4385841530 cites W3168728750 @default.
- W4385841530 cites W3182511770 @default.
- W4385841530 cites W3183478148 @default.
- W4385841530 cites W3200077183 @default.