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- W4385855448 abstract "PFAS (per- and polyfluoroalkyl substances) are organofluorine substances that are used commercially in products like non-stick cookware, food packaging, personal care products, fire-fighting foam, etc. These chemicals have several different subtypes made of varying numbers of carbon and fluorine atoms. PFAS substances that have longer carbon chains, such as PFOS (perfluorooctane sulfonic acid), can potentially pose a significant public health risk due to their ability to bioaccumulate and persist for long periods of time in the body and the environment. The National Academies Report suggests there is some evidence of PFOS exposure and gastrointestinal (GI) inflammation contributing to ulcerative colitis. Inflammatory bowel diseases such as ulcerative colitis are precursors to colorectal cancer. However, evidence about the association between PFOS and colorectal cancer is limited and has shown contradictory findings. This review provides an overview of population and preclinical studies on PFOS exposure and GI inflammation, metabolism, immune responses, and carcinogenesis. It also highlights some mitigation approaches to reduce the harmful effects of PFOS on GI tract and discusses the dietary strategies, such as an increase in soluble fiber intake, to reduce PFOS-induced alterations in cellular lipid metabolism. More importantly, this review demonstrates the urgent need to better understand the relationship between PFOS and GI pathology and carcinogenesis, which will enable development of better approaches for interventions in populations exposed to high levels of PFAS, and in particular to PFOS." @default.
- W4385855448 created "2023-08-17" @default.
- W4385855448 creator A5028933202 @default.
- W4385855448 creator A5046293802 @default.
- W4385855448 creator A5055304592 @default.
- W4385855448 creator A5078400417 @default.
- W4385855448 creator A5084375387 @default.
- W4385855448 date "2023-08-15" @default.
- W4385855448 modified "2023-09-26" @default.
- W4385855448 title "The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis" @default.
- W4385855448 cites W1504303645 @default.
- W4385855448 cites W1701018835 @default.
- W4385855448 cites W1965952181 @default.
- W4385855448 cites W1969826394 @default.
- W4385855448 cites W1984027241 @default.
- W4385855448 cites W1984752955 @default.
- W4385855448 cites W1986406665 @default.
- W4385855448 cites W1993650845 @default.
- W4385855448 cites W1999192743 @default.
- W4385855448 cites W2007043238 @default.
- W4385855448 cites W2008057044 @default.
- W4385855448 cites W2014776577 @default.
- W4385855448 cites W2019813857 @default.
- W4385855448 cites W2038637141 @default.
- W4385855448 cites W2043667147 @default.
- W4385855448 cites W2046972425 @default.
- W4385855448 cites W2060813234 @default.
- W4385855448 cites W2082208126 @default.
- W4385855448 cites W2097143526 @default.
- W4385855448 cites W2101992164 @default.
- W4385855448 cites W2104578573 @default.
- W4385855448 cites W2105640386 @default.
- W4385855448 cites W2107375023 @default.
- W4385855448 cites W2112558380 @default.
- W4385855448 cites W2134031962 @default.
- W4385855448 cites W2136857997 @default.
- W4385855448 cites W2141314779 @default.
- W4385855448 cites W2163614144 @default.
- W4385855448 cites W2210472434 @default.
- W4385855448 cites W2221432805 @default.
- W4385855448 cites W2262329766 @default.
- W4385855448 cites W2277468569 @default.
- W4385855448 cites W2346896306 @default.
- W4385855448 cites W2560030021 @default.
- W4385855448 cites W2605981617 @default.
- W4385855448 cites W2606510632 @default.
- W4385855448 cites W2614197161 @default.
- W4385855448 cites W2619691821 @default.
- W4385855448 cites W2734664239 @default.
- W4385855448 cites W2740695644 @default.
- W4385855448 cites W2766254384 @default.
- W4385855448 cites W2790757017 @default.
- W4385855448 cites W2803637262 @default.
- W4385855448 cites W2898326715 @default.
- W4385855448 cites W2899345691 @default.
- W4385855448 cites W2904612650 @default.
- W4385855448 cites W2911743482 @default.
- W4385855448 cites W2918371302 @default.
- W4385855448 cites W2921969408 @default.
- W4385855448 cites W2951221521 @default.
- W4385855448 cites W2959497269 @default.
- W4385855448 cites W2966389029 @default.
- W4385855448 cites W2986572941 @default.
- W4385855448 cites W2999636890 @default.
- W4385855448 cites W2999754831 @default.
- W4385855448 cites W3009962619 @default.
- W4385855448 cites W3020424172 @default.
- W4385855448 cites W3025130656 @default.
- W4385855448 cites W3037245694 @default.
- W4385855448 cites W3044805203 @default.
- W4385855448 cites W3081586507 @default.
- W4385855448 cites W3083268731 @default.
- W4385855448 cites W3091745167 @default.
- W4385855448 cites W3103794081 @default.
- W4385855448 cites W3107219160 @default.
- W4385855448 cites W3108892830 @default.
- W4385855448 cites W3110058514 @default.
- W4385855448 cites W3111328799 @default.
- W4385855448 cites W3115302287 @default.
- W4385855448 cites W3119765225 @default.
- W4385855448 cites W3120128714 @default.
- W4385855448 cites W3134754607 @default.
- W4385855448 cites W3136539940 @default.
- W4385855448 cites W3137693137 @default.
- W4385855448 cites W3153812187 @default.
- W4385855448 cites W3157088891 @default.
- W4385855448 cites W3158418448 @default.
- W4385855448 cites W3161652808 @default.
- W4385855448 cites W3163361401 @default.
- W4385855448 cites W3179854736 @default.
- W4385855448 cites W3180882235 @default.
- W4385855448 cites W3191996676 @default.
- W4385855448 cites W3195659966 @default.
- W4385855448 cites W3205261510 @default.
- W4385855448 cites W3205708972 @default.
- W4385855448 cites W3209040324 @default.
- W4385855448 cites W3210210996 @default.
- W4385855448 cites W3214135036 @default.
- W4385855448 cites W3214721620 @default.
- W4385855448 cites W3216849526 @default.