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• W4385857504 abstract "ABSTRACTPurpose To describe the clinical and epidemiological characteristics of the first epidemic of Rift Valley Fever retinitis in Rwanda and to report novel imaging findings and a possible role for corticosteroids.Methods Retrospective analysis of all patients who presented with presumed Rift Valley Fever retinitis at the Rwanda Charity Eye Hospital over a period of 4 months in 2022. Multimodal images are reviewed including optical coherence tomography, fluorescein angiography, color, infrared, red-free, and autofluorescence photography.Results The newly identified arciform hyporeflective pattern on infrared imaging was present in 100% of patients. Out of 9 patients treated with oral corticosteroids, 7 (78%) experienced a visual acuity increase of at least 0.2 during follow-up, in comparison to only 4 (28%) out of 14 of untreated patients. Out of four patients treated with a subtenon corticosteroid injection, only one (25%) reached this threshold. Post-hoc pairwise comparison with Bonferroni correction revealed a significant difference in average visual acuity improvement (p = 0.034) between patients receiving oral corticosteroids (0.35 ± 0.07) versus no treatment (0.11 ± 0.04).Conclusion The identified arciform hyporeflective pattern on infrared imaging appears to be characteristic of Rift Valley Fever retinitis and should be known to clinicians working in endemic regions. Compared to a historical cohort and to untreated patients in this non-randomized study, there appears to be a benefit of treatment with oral corticosteroids.ARTICLE SUMMARY STATEMENTThis is the first reported outbreak of Rift Valley Fever retinitis in Rwanda, demonstrating a characteristic arciform peri-macular pattern on infrared imaging not previously published and a possible treatment effect of oral corticosteroids.KEYWORDS: Multimodal imagingretinitisRift Valley Fever AcknowledgmentsWe would like to thank the staff at the Rwanda Charity Eye Hospital for their help in collecting patient data.DisclaimersThis material has not previously been presented.The study adhered to the tenets of the Declaration of Helsinki.Written informed consent was obtained from all patients.Disclosure statementNo potential conflict of interest was reported by the author(s).Ethical approvalEthical committee approval was obtained from the board of the Rwanda Charity Eye Hospital.Data availability statementThis work was done at the Rwanda Charity Eye Hospital in Rwanda. Data are available on request from the authors.Additional informationFundingThe authors did not receive any financial support, nor do they have any proprietary interest." @default.
• W4385857504 created "2023-08-17" @default.
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• W4385857504 date "2023-08-16" @default.
• W4385857504 modified "2023-10-04" @default.
• W4385857504 title "Outbreak of Rift Valley Fever Retinitis in Rwanda: Novel Imaging Findings and Response to Treatment with Corticosteroids" @default.
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• W4385857504 doi "https://doi.org/10.1080/09273948.2023.2246549" @default.
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