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- W4385874812 abstract "This chapter was devoted to prove the capability of starch nanoparticles as a potential nanocarrier in biomedical applications especially for the drug delivery system. Numerous authors had been introduced starch nanoparticles through physically or chemically modifications and their experiments were designed to investigate the morphological study, pH responsiveness studies, in vitro drug release, and kinetic release study of starch nanoparticles with a modeled drug. Further analysis was carried out on the drug releases starch nanoparticles which provided a general statement that percentage of drug released with time from starch nanoparticles was influenced by the pH of physiological media. The obtained data from the release of drug from starch nanoparticles were fitted with different kinetic release equations to determine whether the drug release mechanism was a swelling, diffusion, or surface-erosion controlled system. The drug could release from starch nanoparticles through swelling, surface erosion, or diffusion of the nanoparticles. Thus, the starch nanoparticles were practically a viable solution as a nanocarrier in biomedical applications, with the in vitro release data showing the combination of impressive drug release behavior and sensitivity to the pH of the surrounding medium.This work provides results that suggest the potential of starch nanoparticles as controlled release nanocarriers for drug delivery systems in biomedical applications. The data from the previous experiments can be used as a foundation for future research. More detailed work needs to be carried out to find accurate information on physical and chemical behavior can be obtained to improve the material performance. Future recommended research can involve the in vivo drug release from starch nanoparticles and clinical trials. This is crucial because such data could be used as a future guideline to produced starch nanocarrier with better clinical response, tolerability, and lower side effects towards human. Other future extension can be the study of synthesis conditions of starch nanoparticles, the biocompatibility of the material with a different type of drug and other relevant parameters." @default.
- W4385874812 created "2023-08-17" @default.
- W4385874812 creator A5044397796 @default.
- W4385874812 date "2023-08-15" @default.
- W4385874812 modified "2023-10-04" @default.
- W4385874812 title "Nanotechnology in biomedical application: pH-responsive starch nanoparticles" @default.
- W4385874812 doi "https://doi.org/10.1049/pbhe054e_ch20" @default.
- W4385874812 hasPublicationYear "2023" @default.
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