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- W4385875357 abstract "Abstract The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations ( BAZ2B and DDIAS ). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP . Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort." @default.
- W4385875357 created "2023-08-17" @default.
- W4385875357 creator A5077296737 @default.
- W4385875357 date "2023-08-15" @default.
- W4385875357 modified "2023-10-04" @default.
- W4385875357 title "Novel risk loci for COVID-19 hospitalization among admixed American populations" @default.
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- W4385875357 doi "https://doi.org/10.1101/2023.08.11.23293871" @default.
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