FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385875802> ?p ?o ?g. }

• W4385875802 abstract "Abstract Background Non-alcoholic fatty liver disease (NAFLD) has been well defined as a common chronic liver metabolism disorder. Statins as a first-line therapeutic treatment had some side effects. Here, we found that Fumigaclavine C (FC) was collected from endophytic Aspergillus terreus via the root of Rhizophora stylosa (Rhizophoraceae), had potential anti-adipogenic and hepatoprotective effects both in vitro and in vivo without obvious adverse side effects. However, the mechanisms of the prevention and management of FC for hepatic steatosis are incompletely delineated. Methods The pharmacodynamic effects of FC were measured in high-fat diet (HFD)-induced obese mice. Liver index and blood biochemical were examined. Histopathological examination in the liver was performed by hematoxylin & eosin or oil red O. The levels of serum TG, TC, LDL-c, HDL-c, FFA, T-bili, ALT, AST, creatinine, and creatine kinase were estimated via diagnostic assay kits. The levels of hepatic lipid metabolism-related genes were detected via qRT-PCR. The expression levels of hepatic de novo lipogenesis were quantitated with Western blot analysis. Results FC-treatment markedly reduced hepatic lipid accumulation in HFD-induced obese mice. FC significantly attenuated the hepatic lipid metabolism and ameliorated liver injury without obvious adverse side effects. Moreover, FC also could dose-dependently modulate the expressions of lipid metabolism-related transcription genes. Mechanically, FC notably suppressed sterol response element binding protein-1c mediated de novo lipogenesis via interfering with the RhoA/ROCK signaling pathway by decreasing the levels of geranylgeranyl diphosphate and farnesyl diphosphate. Conclusions These findings suggested that FC could improve hepatic steatosis through inhibiting de novo lipogenesis via modulating the RhoA/ROCK signaling pathway." @default.
• W4385875802 created "2023-08-17" @default.
• W4385875802 creator A5003905982 @default.
• W4385875802 creator A5004858645 @default.
• W4385875802 creator A5029885119 @default.
• W4385875802 creator A5046907412 @default.
• W4385875802 creator A5053356283 @default.
• W4385875802 creator A5083903397 @default.
• W4385875802 date "2023-08-16" @default.
• W4385875802 modified "2023-10-16" @default.
• W4385875802 title "Fumigaclavine C ameliorates liver steatosis by attenuating hepatic de novo lipogenesis via modulation of the RhoA/ROCK signaling pathway" @default.
• W4385875802 cites W1901618415 @default.
• W4385875802 cites W1985592156 @default.
• W4385875802 cites W1996090974 @default.
• W4385875802 cites W2021182361 @default.
• W4385875802 cites W2032661184 @default.
• W4385875802 cites W2039292467 @default.
• W4385875802 cites W2088152857 @default.
• W4385875802 cites W2139351004 @default.
• W4385875802 cites W2146544786 @default.
• W4385875802 cites W2159811344 @default.
• W4385875802 cites W2168359048 @default.
• W4385875802 cites W2182670456 @default.
• W4385875802 cites W2282840772 @default.
• W4385875802 cites W2295859050 @default.
• W4385875802 cites W2333398313 @default.
• W4385875802 cites W2412393850 @default.
• W4385875802 cites W243927228 @default.
• W4385875802 cites W2536805338 @default.
• W4385875802 cites W2622227790 @default.
• W4385875802 cites W2747071866 @default.
• W4385875802 cites W2942206379 @default.
• W4385875802 cites W2982993959 @default.
• W4385875802 cites W2995274366 @default.
• W4385875802 cites W3011975362 @default.
• W4385875802 cites W3016796116 @default.
• W4385875802 cites W3032722056 @default.
• W4385875802 cites W3086628630 @default.
• W4385875802 cites W3087060133 @default.
• W4385875802 cites W3087618888 @default.
• W4385875802 cites W3094270663 @default.
• W4385875802 cites W3106831132 @default.
• W4385875802 cites W3110872761 @default.
• W4385875802 cites W3129406019 @default.
• W4385875802 cites W3163475530 @default.
• W4385875802 cites W36612387 @default.
• W4385875802 cites W4224940969 @default.
• W4385875802 cites W4252021281 @default.
• W4385875802 cites W4289931769 @default.
• W4385875802 cites W4292615794 @default.
• W4385875802 cites W4297491757 @default.
• W4385875802 cites W4324311167 @default.
• W4385875802 cites W4362506454 @default.
• W4385875802 cites W3160028939 @default.
• W4385875802 doi "https://doi.org/10.1186/s12906-023-04110-9" @default.
• W4385875802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37587459" @default.
• W4385875802 hasPublicationYear "2023" @default.
• W4385875802 type Work @default.
• W4385875802 citedByCount "0" @default.
• W4385875802 crossrefType "journal-article" @default.
• W4385875802 hasAuthorship W4385875802A5003905982 @default.
• W4385875802 hasAuthorship W4385875802A5004858645 @default.
• W4385875802 hasAuthorship W4385875802A5029885119 @default.
• W4385875802 hasAuthorship W4385875802A5046907412 @default.
• W4385875802 hasAuthorship W4385875802A5053356283 @default.
• W4385875802 hasAuthorship W4385875802A5083903397 @default.
• W4385875802 hasBestOaLocation W43858758021 @default.
• W4385875802 hasConcept C126322002 @default.
• W4385875802 hasConcept C134018914 @default.
• W4385875802 hasConcept C141359234 @default.
• W4385875802 hasConcept C185592680 @default.
• W4385875802 hasConcept C2776175330 @default.
• W4385875802 hasConcept C2776637226 @default.
• W4385875802 hasConcept C2776954865 @default.
• W4385875802 hasConcept C2777093181 @default.
• W4385875802 hasConcept C2778772119 @default.
• W4385875802 hasConcept C2779134260 @default.
• W4385875802 hasConcept C4733338 @default.
• W4385875802 hasConcept C55493867 @default.
• W4385875802 hasConcept C62478195 @default.
• W4385875802 hasConcept C71924100 @default.
• W4385875802 hasConcept C86803240 @default.
• W4385875802 hasConceptScore W4385875802C126322002 @default.
• W4385875802 hasConceptScore W4385875802C134018914 @default.
• W4385875802 hasConceptScore W4385875802C141359234 @default.
• W4385875802 hasConceptScore W4385875802C185592680 @default.
• W4385875802 hasConceptScore W4385875802C2776175330 @default.
• W4385875802 hasConceptScore W4385875802C2776637226 @default.
• W4385875802 hasConceptScore W4385875802C2776954865 @default.
• W4385875802 hasConceptScore W4385875802C2777093181 @default.
• W4385875802 hasConceptScore W4385875802C2778772119 @default.
• W4385875802 hasConceptScore W4385875802C2779134260 @default.
• W4385875802 hasConceptScore W4385875802C4733338 @default.
• W4385875802 hasConceptScore W4385875802C55493867 @default.
• W4385875802 hasConceptScore W4385875802C62478195 @default.
• W4385875802 hasConceptScore W4385875802C71924100 @default.
• W4385875802 hasConceptScore W4385875802C86803240 @default.
• W4385875802 hasFunder F4320321001 @default.
• W4385875802 hasIssue "1" @default.
• W4385875802 hasLocation W43858758021 @default.

• next