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- W4385876871 abstract "In this experiment, a novel synthetic approach is performed to produce sulfanilamide, a “sulfa” drug that contributed to the proliferation of many antibacterials in the early 20th century. Despite the early ubiquitous use of sulfanilamide as a front-line remedy, no synthesis pathway is feasibly accomplished with safe reagents and in a timely manner. Commonly, aniline would be protected followed by sulfonation with gaseous SO2 and deprotection. A Willis reagent allows for a modern and convenient alternate route that involves a one step addition with a Grignard to produce the final sulfonamide after workup. The generation of the short-lived Willis reagent from commercially available starting products is confirmed as well as its efficacy to add a sulfinyl group to the substrate." @default.
- W4385876871 created "2023-08-17" @default.
- W4385876871 creator A5038308959 @default.
- W4385876871 date "2023-08-16" @default.
- W4385876871 modified "2023-10-04" @default.
- W4385876871 title "Sulfanilamide Synthesis with a Modern Silyl-Sulfinylamine Willis Reagent" @default.
- W4385876871 doi "https://doi.org/10.26434/chemrxiv-2023-xp92p" @default.
- W4385876871 hasPublicationYear "2023" @default.
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