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- W4385877690 endingPage "12837" @default.
- W4385877690 startingPage "12837" @default.
- W4385877690 abstract "The microenvironment of most tumors is complex, comprising numerous aspects of immunosuppression. Several studies have indicated that the adrenergic system is vital for controlling immunological responses. In the context of the tumor microenvironment, nor-adrenaline (NA) is poured in by innervating nerves and tumor tissues itself. The receptors for nor-adrenaline are present on the surfaces of cancer and immune cells and are often involved in the activation of pro-tumoral signaling pathways. Beta2-adrenergic receptors (β2-ARs) are an emerging class of receptors that are capable of modulating the functioning of immune cells. β2-AR is reported to activate regulatory immune cells and inhibit effector immune cells. Blocking β2-AR increases activation, proliferation, and cytokine release of T lymphocytes. Moreover, β2-AR deficiency during metabolic reprogramming of T cells increases mitochondrial membrane potential and biogenesis. In the view of the available research data, the immunosuppressive role of β2-AR in T cells presents it as a targetable checkpoint in CAR-T cell therapies. In this review, we have abridged the contemporary knowledge about adrenergic-stress-mediated β2-AR activation on T lymphocytes inside tumor milieu." @default.
- W4385877690 created "2023-08-17" @default.
- W4385877690 creator A5001799989 @default.
- W4385877690 creator A5005232437 @default.
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- W4385877690 creator A5058073627 @default.
- W4385877690 creator A5060310796 @default.
- W4385877690 creator A5082935369 @default.
- W4385877690 date "2023-08-16" @default.
- W4385877690 modified "2023-10-14" @default.
- W4385877690 title "β2-Adrenergic Receptor Mediated Inhibition of T Cell Function and Its Implications for CAR-T Cell Therapy" @default.
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