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- W4385877807 abstract "<p>Supplementary Figure S4: Antibiotics use in relation to survival outcomes in stage I-III colorectal cancer (crude and completecasemultivariable analyses).(A) Antibiotics use in relation to overall survival. (B) Antibiotics use in relation to cancer-specific survival.Prediagnostic antibiotics use was categorized as no use, any use, low use (1-10 days), moderate use (11-60days), high use (61-180 days) and very high use (>180 days), based on defined daily doses. Antibiotics useduring one year before colorectal cancer diagnosis was excluded to account for potential use due toundiagnosed but clinically manifest colorectal cancer. CI = confidence interval; HR = Hazard Ratio. Model 0 iscrude or univariable Cox analysis. Model 1 is a Cox proportional hazard model including main demographic andsocioeconomic factors (age and calendar year of diagnosis and prediagnostic Charlson comorbidity index ascontinuous variables, and sex, place of birth, county of residence, marital status, level of education, incomestatus and family history of colorectal cancer as categorical variables). Model 2 includes tumour sites andtumour stage in addition to the covariates in model 1. Model 3 includes therapy-related variables such asoperation type, preoperative chemotherapy (yes/no) and preoperative radiotherapy (yes/no) in addition tocovariates in model 2. Variable definitions and categorization for the covariates in models 1-3 are as presentedin Table 1. For each multivariable model, variables violating the proportional hazard assumption werecontrolled for by stratification in the respective models. They were age at diagnosis (</≥ 50 years), sex(men/women), prediagnostic Charlson comorbidity index (CCI) (no/any comorbidity), income status (quartilecategories) and family history of colorectal cancer (0/1/≥2 first degree relatives) for model 1; age at diagnosis,prediagnostic CCI, family history of colorectal cancer, tumour sites (proximal colon, distal colon, rectum,unspecified) and tumour stage (stage I-III) for model 2, age at diagnosis, prediagnostic CCI, type of surgery2(elective/emergency), tumour sites and tumour stage for model 3. For age at diagnosis and prediagnostic CCI (continuous variables), binary variable types (age at diagnosis: </≥ 50 years, prediagnostic CCI: no/any CCI) were used and continuous variable types were also adjusted to account for residual confounding in each stratum.</p></p>" @default.
- W4385877807 created "2023-08-17" @default.
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- W4385877807 date "2023-08-16" @default.
- W4385877807 modified "2023-10-04" @default.
- W4385877807 title "Supplementary Figure S4 from Prediagnostic Prescription Antibiotics Use and Survival in Patients with Colorectal Cancer: A Swedish National Register-based Study" @default.
- W4385877807 doi "https://doi.org/10.1158/1055-9965.23968694" @default.
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