Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385879423> ?p ?o ?g. }
- W4385879423 abstract "Disulfidptosis is a newly-identified non-programmed cell death mode with tight associations with glucose metabolism. Elevated glycolysis is an important metabolic feature of tumor cells, which fulfills the energy requirement for their rapid growth and progression. Our present study determined to develop a disulfidptosis and glycolysis related gene (DGRG) risk score signature to predict the prognosis and ICI therapeutic responsiveness for CRC patients. First, the gene expression and clinical profiles for CRC patients were obtained from TCGA and GEO database. Using weighted gene co-expression network analysis, we identified hub genes showing the strongest correlations with both disulfidptosis and glycolysis activities. Next, a DGRG risk score signature was successfully developed through univariate and least absolute shrinkage and selection operator method Cox regression method. A DGRG risk score-based nomogram could further enhance the predictive performance. In addition, an array of systemic analysis was performed to unravel the correlation of DGRG risk score with tumor microenvironment. The results showed that CRC patients with low DGRG risk level had up-regulated immune cell infiltrations, enhanced metabolic activities and heightened gene mutation frequencies, while high risk patients was the opposite. Moreover, our present study identified low risk CRC patients as potential beneficiaries from immune checkpoint inhibitor (ICI) therapies. Our present work highlighted the potential utility of DGRG risk score signature in prognosis prediction and ICI responsiveness determination for CRC patients, which demonstrated promising clinical application value." @default.
- W4385879423 created "2023-08-17" @default.
- W4385879423 creator A5015082378 @default.
- W4385879423 creator A5040775416 @default.
- W4385879423 creator A5068228255 @default.
- W4385879423 date "2023-08-16" @default.
- W4385879423 modified "2023-09-30" @default.
- W4385879423 title "A novel disulfidptosis and glycolysis related risk score signature for prediction of prognosis and ICI therapeutic responsiveness in colorectal cancer" @default.
- W4385879423 cites W1607790980 @default.
- W4385879423 cites W1966107523 @default.
- W4385879423 cites W1994993231 @default.
- W4385879423 cites W2031628684 @default.
- W4385879423 cites W2035618305 @default.
- W4385879423 cites W2037342985 @default.
- W4385879423 cites W2066671159 @default.
- W4385879423 cites W2075294566 @default.
- W4385879423 cites W2117692326 @default.
- W4385879423 cites W2121141922 @default.
- W4385879423 cites W2140875987 @default.
- W4385879423 cites W2161691060 @default.
- W4385879423 cites W2177971463 @default.
- W4385879423 cites W2296807971 @default.
- W4385879423 cites W2341673931 @default.
- W4385879423 cites W2560367415 @default.
- W4385879423 cites W2606081897 @default.
- W4385879423 cites W2739132742 @default.
- W4385879423 cites W2762602728 @default.
- W4385879423 cites W2763584377 @default.
- W4385879423 cites W2785803176 @default.
- W4385879423 cites W2886190807 @default.
- W4385879423 cites W2889052854 @default.
- W4385879423 cites W2896872272 @default.
- W4385879423 cites W2909679049 @default.
- W4385879423 cites W2911292434 @default.
- W4385879423 cites W2943793201 @default.
- W4385879423 cites W2948469290 @default.
- W4385879423 cites W2950756851 @default.
- W4385879423 cites W2990730560 @default.
- W4385879423 cites W2991341799 @default.
- W4385879423 cites W3000701846 @default.
- W4385879423 cites W3012408003 @default.
- W4385879423 cites W3080945733 @default.
- W4385879423 cites W3089498703 @default.
- W4385879423 cites W3092226358 @default.
- W4385879423 cites W3093091935 @default.
- W4385879423 cites W3096828292 @default.
- W4385879423 cites W3103119004 @default.
- W4385879423 cites W3118913605 @default.
- W4385879423 cites W3128646645 @default.
- W4385879423 cites W3148678459 @default.
- W4385879423 cites W3171517418 @default.
- W4385879423 cites W3179304282 @default.
- W4385879423 cites W3185587603 @default.
- W4385879423 cites W3187790888 @default.
- W4385879423 cites W3197262372 @default.
- W4385879423 cites W3204369339 @default.
- W4385879423 cites W3204465543 @default.
- W4385879423 cites W3210746946 @default.
- W4385879423 cites W4200125155 @default.
- W4385879423 cites W4200452949 @default.
- W4385879423 cites W4206384216 @default.
- W4385879423 cites W4226440498 @default.
- W4385879423 cites W4281683023 @default.
- W4385879423 cites W4283738750 @default.
- W4385879423 cites W4293224264 @default.
- W4385879423 cites W4294771465 @default.
- W4385879423 cites W4296907702 @default.
- W4385879423 cites W4313396397 @default.
- W4385879423 cites W4313432270 @default.
- W4385879423 cites W4315700061 @default.
- W4385879423 cites W4318240947 @default.
- W4385879423 cites W4318486204 @default.
- W4385879423 cites W4319310752 @default.
- W4385879423 cites W4320917536 @default.
- W4385879423 doi "https://doi.org/10.1038/s41598-023-40381-5" @default.
- W4385879423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37587262" @default.
- W4385879423 hasPublicationYear "2023" @default.
- W4385879423 type Work @default.
- W4385879423 citedByCount "0" @default.
- W4385879423 crossrefType "journal-article" @default.
- W4385879423 hasAuthorship W4385879423A5015082378 @default.
- W4385879423 hasAuthorship W4385879423A5040775416 @default.
- W4385879423 hasAuthorship W4385879423A5068228255 @default.
- W4385879423 hasBestOaLocation W43858794231 @default.
- W4385879423 hasConcept C104317684 @default.
- W4385879423 hasConcept C11783203 @default.
- W4385879423 hasConcept C119857082 @default.
- W4385879423 hasConcept C121608353 @default.
- W4385879423 hasConcept C126322002 @default.
- W4385879423 hasConcept C143998085 @default.
- W4385879423 hasConcept C150194340 @default.
- W4385879423 hasConcept C161584116 @default.
- W4385879423 hasConcept C199163554 @default.
- W4385879423 hasConcept C2779134260 @default.
- W4385879423 hasConcept C2779733811 @default.
- W4385879423 hasConcept C34626388 @default.
- W4385879423 hasConcept C41008148 @default.
- W4385879423 hasConcept C50382708 @default.
- W4385879423 hasConcept C526805850 @default.
- W4385879423 hasConcept C54355233 @default.