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• W4385879462 endingPage "109715" @default.
• W4385879462 startingPage "109715" @default.
• W4385879462 abstract "The widespread use of silica nanoparticles (SiO2-NPs) in various industries, including chemical polishing, cosmetics, varnishes, medical, and food products, has increased the risk of their release into aquatic ecosystems. The toxic effects of small-size SiO2-NPs on the reproductive performance of zebrafish (Danio rerio) have yet to be widely studied. This study aimed to investigate the impact of chronic exposure to small-sized (35 ± 6 nm) SiO2-NPs on adult zebrafish through waterborne exposure to concentrations of 5 (SNP5), 10 (SNP10), 15 (SNP15), and 20 (SNP20) μg/L of SiO2-NPs for 28 days. Our results showed that SiO2-NPs significantly impacted several biochemical parameters, including cholesterol, triglycerides, LDL, HDL, total protein, albumin, urea levels, and alkaline phosphatase and aspartate aminotransferase activity. Cortisol and glucose levels in the SNP20 group significantly differed from the control group. All the exposed groups, apart from SNP5, experienced a significant increase in their total immunoglobulin levels and lysozyme activity. While there was a considerable increase in the activity of catalase and superoxide dismutase in all exposed groups, the expression of antioxidant genes did not appear to be affected. Furthermore, the expression level of il8 was significantly higher in SNP5 and SNP10 than in other treatments. Exposure to SiO2-NPs caused a decrease in gonad weight, absolute fecundity, and larval survival rate, particularly in the SNP20 group. In summary, this study indicates that SiO2-NPs can harm zebrafish, and thus further research is necessary to assess their health and environmental risks." @default.
• W4385879462 created "2023-08-17" @default.
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• W4385879462 date "2023-11-01" @default.
• W4385879462 modified "2023-09-27" @default.
• W4385879462 title "Long-term exposure to small-sized silica nanoparticles (SiO2-NPs) induces oxidative stress and impairs reproductive performance in adult zebrafish (Danio rerio)" @default.
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• W4385879462 doi "https://doi.org/10.1016/j.cbpc.2023.109715" @default.
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